Hepatitis C virus infection in patients with leukemia
We have studied 30 patients with acute leukemia by the second‐generation assay for antibodies to hepatitis C virus (HCV) to determine the incidence of HCV infection and the impact of anti‐HCV positivity on liver disease. After a complete remission, 21/30 (70%) patients were anti‐HCV‐positive. During...
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| Veröffentlicht in: | American journal of hematology 1994-08, Vol.46 (4), p.278-282 |
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| container_title | American journal of hematology |
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| creator | Fujii, Yasuhiko Kaku, Kohei Tanaka, Masahisa Yosizaki, Miki Kaneko, Toshio Matumoto, Noboru |
| description | We have studied 30 patients with acute leukemia by the second‐generation assay for antibodies to hepatitis C virus (HCV) to determine the incidence of HCV infection and the impact of anti‐HCV positivity on liver disease. After a complete remission, 21/30 (70%) patients were anti‐HCV‐positive. During chemotherapy the anti‐HCV‐positive patients had more severe liver disease than the anti‐HCV‐negative patients, and they had a higher incidence of chronic hepatitis (13/21; 62% vs. 1/9; 11%, P < 0.01). During subsequent follow‐up, 15/30 (50%) patients relapsed and 15/30 (50%) patients completed the chemotherapy protocols. After a relapse 12/15 (80%) patients were anti‐HCV‐positive and they had more severe liver disease than the anti‐HCV‐negative patients. Among the patients who completed chemotherapy (n = 15), biochemical evidence of chronic hepatitis was found in 9/9 (100%) anti‐HCV‐positive, and 2/6 (33%) anti‐HCV‐negative cases during off‐therapy follow‐up after therapy‐withdrawal (P < 0.05). These results indicate that HCV plays an important role in the etiology of chronic hepatitis which could worsen the final prognosis of successfully treated patients with leukemia. © 1994 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajh.2830460405 |
| format | Article |
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After a complete remission, 21/30 (70%) patients were anti‐HCV‐positive. During chemotherapy the anti‐HCV‐positive patients had more severe liver disease than the anti‐HCV‐negative patients, and they had a higher incidence of chronic hepatitis (13/21; 62% vs. 1/9; 11%, P < 0.01). During subsequent follow‐up, 15/30 (50%) patients relapsed and 15/30 (50%) patients completed the chemotherapy protocols. After a relapse 12/15 (80%) patients were anti‐HCV‐positive and they had more severe liver disease than the anti‐HCV‐negative patients. Among the patients who completed chemotherapy (n = 15), biochemical evidence of chronic hepatitis was found in 9/9 (100%) anti‐HCV‐positive, and 2/6 (33%) anti‐HCV‐negative cases during off‐therapy follow‐up after therapy‐withdrawal (P < 0.05). These results indicate that HCV plays an important role in the etiology of chronic hepatitis which could worsen the final prognosis of successfully treated patients with leukemia. © 1994 Wiley‐Liss, Inc.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.2830460405</identifier><identifier>PMID: 8037177</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Chronic Disease ; Female ; Hepatitis Antibodies - analysis ; Hepatitis C - blood ; Hepatitis C - diagnosis ; Hepatitis C - immunology ; hepatitis C virus ; Humans ; leukemia ; Leukemia - microbiology ; Liver Diseases - microbiology ; Male ; Middle Aged ; Serologic Tests ; transfusion</subject><ispartof>American journal of hematology, 1994-08, Vol.46 (4), p.278-282</ispartof><rights>Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3695-825d337e360837090006903b2bb6b4a6c69952ce2fc6d90d15e13fc04ada2b1c3</citedby><cites>FETCH-LOGICAL-c3695-825d337e360837090006903b2bb6b4a6c69952ce2fc6d90d15e13fc04ada2b1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajh.2830460405$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajh.2830460405$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8037177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujii, Yasuhiko</creatorcontrib><creatorcontrib>Kaku, Kohei</creatorcontrib><creatorcontrib>Tanaka, Masahisa</creatorcontrib><creatorcontrib>Yosizaki, Miki</creatorcontrib><creatorcontrib>Kaneko, Toshio</creatorcontrib><creatorcontrib>Matumoto, Noboru</creatorcontrib><title>Hepatitis C virus infection in patients with leukemia</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>We have studied 30 patients with acute leukemia by the second‐generation assay for antibodies to hepatitis C virus (HCV) to determine the incidence of HCV infection and the impact of anti‐HCV positivity on liver disease. After a complete remission, 21/30 (70%) patients were anti‐HCV‐positive. During chemotherapy the anti‐HCV‐positive patients had more severe liver disease than the anti‐HCV‐negative patients, and they had a higher incidence of chronic hepatitis (13/21; 62% vs. 1/9; 11%, P < 0.01). During subsequent follow‐up, 15/30 (50%) patients relapsed and 15/30 (50%) patients completed the chemotherapy protocols. After a relapse 12/15 (80%) patients were anti‐HCV‐positive and they had more severe liver disease than the anti‐HCV‐negative patients. Among the patients who completed chemotherapy (n = 15), biochemical evidence of chronic hepatitis was found in 9/9 (100%) anti‐HCV‐positive, and 2/6 (33%) anti‐HCV‐negative cases during off‐therapy follow‐up after therapy‐withdrawal (P < 0.05). These results indicate that HCV plays an important role in the etiology of chronic hepatitis which could worsen the final prognosis of successfully treated patients with leukemia. © 1994 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Hepatitis Antibodies - analysis</subject><subject>Hepatitis C - blood</subject><subject>Hepatitis C - diagnosis</subject><subject>Hepatitis C - immunology</subject><subject>hepatitis C virus</subject><subject>Humans</subject><subject>leukemia</subject><subject>Leukemia - microbiology</subject><subject>Liver Diseases - microbiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Serologic Tests</subject><subject>transfusion</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAURS0EKqWwsiFlYkt5tmPHHquKUlAlFpgtx3lRXfJR4oSq_55UrYCN6V3p3neGQ8gthSkFYA92s54yxSGRkIA4I2MKWsZKCnZOxsAlHTLoS3IVwgaA0kTBiIwU8JSm6ZiIJW5t5zsfonn05ds-RL4u0HW-qYcUHUqsuxDtfLeOSuw_sPL2mlwUtgx4c7oT8r54fJsv49Xr0_N8toodl1rEiomc8xS5BMVT0AAgNfCMZZnMEiud1Fowh6xwMteQU4GUFw4Sm1uWUccn5P7I3bbNZ4-hM5UPDsvS1tj0waRS6IQqNgynx6FrmxBaLMy29ZVt94aCOXgygyfz62l4uDuR-6zC_Gd-EjP0-tjvfIn7f2hm9rL8w_4GpENydg</recordid><startdate>199408</startdate><enddate>199408</enddate><creator>Fujii, Yasuhiko</creator><creator>Kaku, Kohei</creator><creator>Tanaka, Masahisa</creator><creator>Yosizaki, Miki</creator><creator>Kaneko, Toshio</creator><creator>Matumoto, Noboru</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199408</creationdate><title>Hepatitis C virus infection in patients with leukemia</title><author>Fujii, Yasuhiko ; Kaku, Kohei ; Tanaka, Masahisa ; Yosizaki, Miki ; Kaneko, Toshio ; Matumoto, Noboru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3695-825d337e360837090006903b2bb6b4a6c69952ce2fc6d90d15e13fc04ada2b1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Hepatitis Antibodies - analysis</topic><topic>Hepatitis C - blood</topic><topic>Hepatitis C - diagnosis</topic><topic>Hepatitis C - immunology</topic><topic>hepatitis C virus</topic><topic>Humans</topic><topic>leukemia</topic><topic>Leukemia - microbiology</topic><topic>Liver Diseases - microbiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Serologic Tests</topic><topic>transfusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujii, Yasuhiko</creatorcontrib><creatorcontrib>Kaku, Kohei</creatorcontrib><creatorcontrib>Tanaka, Masahisa</creatorcontrib><creatorcontrib>Yosizaki, Miki</creatorcontrib><creatorcontrib>Kaneko, Toshio</creatorcontrib><creatorcontrib>Matumoto, Noboru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujii, Yasuhiko</au><au>Kaku, Kohei</au><au>Tanaka, Masahisa</au><au>Yosizaki, Miki</au><au>Kaneko, Toshio</au><au>Matumoto, Noboru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis C virus infection in patients with leukemia</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>1994-08</date><risdate>1994</risdate><volume>46</volume><issue>4</issue><spage>278</spage><epage>282</epage><pages>278-282</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><abstract>We have studied 30 patients with acute leukemia by the second‐generation assay for antibodies to hepatitis C virus (HCV) to determine the incidence of HCV infection and the impact of anti‐HCV positivity on liver disease. After a complete remission, 21/30 (70%) patients were anti‐HCV‐positive. During chemotherapy the anti‐HCV‐positive patients had more severe liver disease than the anti‐HCV‐negative patients, and they had a higher incidence of chronic hepatitis (13/21; 62% vs. 1/9; 11%, P < 0.01). During subsequent follow‐up, 15/30 (50%) patients relapsed and 15/30 (50%) patients completed the chemotherapy protocols. After a relapse 12/15 (80%) patients were anti‐HCV‐positive and they had more severe liver disease than the anti‐HCV‐negative patients. Among the patients who completed chemotherapy (n = 15), biochemical evidence of chronic hepatitis was found in 9/9 (100%) anti‐HCV‐positive, and 2/6 (33%) anti‐HCV‐negative cases during off‐therapy follow‐up after therapy‐withdrawal (P < 0.05). These results indicate that HCV plays an important role in the etiology of chronic hepatitis which could worsen the final prognosis of successfully treated patients with leukemia. © 1994 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8037177</pmid><doi>10.1002/ajh.2830460405</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Chronic Disease Female Hepatitis Antibodies - analysis Hepatitis C - blood Hepatitis C - diagnosis Hepatitis C - immunology hepatitis C virus Humans leukemia Leukemia - microbiology Liver Diseases - microbiology Male Middle Aged Serologic Tests transfusion |
| title | Hepatitis C virus infection in patients with leukemia |
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