GABA-B receptor-mediated spinal inhibition

THE intravenous administration to pentobarbitone-anaesthetized cats of the GABA-B antagonists CGP 46381 and CGP 35348 blocks the longer duration component of the inhibition of lumbar extensor monosynaptic reflexes by tetanic stimulation of low threshold flexor primary afferent fibres. GABA-B recepto...

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Veröffentlicht in:	Neuroreport 1994-01, Vol.5 (5), p.540-542
Hauptverfasser:	Curtis, David R, Lacey, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - drug effects Animals Baclofen - antagonists & inhibitors Bicuculline - pharmacology Biological and medical sciences Cats Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Decerebrate State - physiopathology Depression, Chemical Fundamental and applied biological sciences. Psychology GABA Antagonists gamma-Aminobutyric Acid - physiology Organophosphorus Compounds - pharmacology Phosphinic Acids - pharmacology Receptors, GABA - classification Receptors, GABA - physiology Reflex, Monosynaptic - drug effects Spinal Cord - drug effects Spinal Cord - physiopathology Tetany - physiopathology Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	THE intravenous administration to pentobarbitone-anaesthetized cats of the GABA-B antagonists CGP 46381 and CGP 35348 blocks the longer duration component of the inhibition of lumbar extensor monosynaptic reflexes by tetanic stimulation of low threshold flexor primary afferent fibres. GABA-B receptors thus appear to be associated with this inhibitory process, in addition to bicuculline-sensitive GABA-A receptors associated with shorter duration ‘presynaptic’ inhibition of reflexes and the depolarization of the terminals of primary afferent fibres.
ISSN:	0959-4965 1473-558X
DOI:	10.1097/00001756-199401000-00002