A yeast artificial chromosome contig on mouse chromosome 11 encompassing the nu locus

Mutations at the nude locus disrupt the homing process of T cell progenitor cells to the thymic rudiment, a key aspect of T cell differentiation. Here, we map the nude locus to a set of overlapping yeast artificial chromosomes (YAC) clones covering a genetic interval of about 0.5 centi Morgan on mou...

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Veröffentlicht in:	European journal of immunology 1994-07, Vol.24 (7), p.1721-1723
Hauptverfasser:	Nehls, Michael, Lüno, Karsten, Schorpp, Michael, Krause, Sabine, Matysiak‐Scholze, Uta, Prokop, Christa‐Maria, Hedrich, Hans J., Boehm, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Chromosome Mapping - veterinary Chromosomes, Artificial, Yeast Crosses, Genetic Fundamental and applied biological sciences. Psychology Fundamental immunology Genetic Markers Immune deficiency Immunobiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Nude - genetics Molecular Sequence Data Mouse Mutation Nude YAC
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Zusammenfassung:	Mutations at the nude locus disrupt the homing process of T cell progenitor cells to the thymic rudiment, a key aspect of T cell differentiation. Here, we map the nude locus to a set of overlapping yeast artificial chromosomes (YAC) clones covering a genetic interval of about 0.5 centi Morgan on mouse chromosome 11. These results provide a suitable starting point to molecularly clone the nude gene.
ISSN:	0014-2980 1521-4141
DOI:	10.1002/eji.1830240742