Changes in the low-density lipoprotein profile during 17β-estradiol-dydrogesterone therapy in postmenopausal women

Changes in the low-density lipoprotein (LDL) subfractions, determined with gradient gel electrophoresis (GGE), were prospectively studied during hormone replacement therapy (HRT) in 23 healthy nonhysterectomized postmenopausal women. LDL subfractions were analyzed by densitometric scanning of the ge...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 1994-07, Vol.43 (7), p.799-802
Hauptverfasser:	van der Mooren, Marius J., de Graaf, Jacqueline, Demacker, Pierre N.M., de Haan, Anton F.J., Rolland, Rune
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Dydrogesterone - therapeutic use Electrophoresis Estradiol - therapeutic use Estrogen Replacement Therapy Female Hormones. Endocrine system Humans Lipids - blood Lipoproteins, LDL - blood Medical sciences Middle Aged Pharmacology. Drug treatments Postmenopause Regression Analysis
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Zusammenfassung:	Changes in the low-density lipoprotein (LDL) subfractions, determined with gradient gel electrophoresis (GGE), were prospectively studied during hormone replacement therapy (HRT) in 23 healthy nonhysterectomized postmenopausal women. LDL subfractions were analyzed by densitometric scanning of the gels. We observed significant changes in the LDL subfraction profile toward a smaller particle size ( P < .001). These changes could almost completely be attributed to the hormonal treatment regimen ( P < .01), and may indicate an effect partially opposite to the other reported changes in the lipid profile.
ISSN:	0026-0495 1532-8600
DOI:	10.1016/0026-0495(94)90256-9