Purine Acyclic Nucleosides. 6-Dimethylamino-9-[(2-phenylalanylamido-1-substituted-ethoxy)methyl]purines as Candidate Antivirals
Several acyclic puromycin analogues containing hydrocarbon substituents on the 1′-position of the aminoethoxymethyl moiety were synthesized and tested for antiviral activity. The N-carbobenzoxy intermediate 7c was active in vitro against Mengo and Semliki Forest viruses.
Gespeichert in:
| Veröffentlicht in: | Journal of pharmaceutical sciences 1985-12, Vol.74 (12), p.1302-1304 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1304 |
|---|---|
| container_issue | 12 |
| container_start_page | 1302 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 74 |
| creator | Kelley, James L. Selway, J.W.T. Schaeffer, Howard J. |
| description | Several acyclic puromycin analogues containing hydrocarbon substituents on the 1′-position of the aminoethoxymethyl moiety were synthesized and tested for antiviral activity. The N-carbobenzoxy intermediate 7c was active in vitro against Mengo and Semliki Forest viruses. |
| doi_str_mv | 10.1002/jps.2600741211 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76582763</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022354915469709</els_id><sourcerecordid>76582763</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4561-c52668e5c69728ade110d3518e30b17b4f23502dbcef7953afc66776a9f111d3</originalsourceid><addsrcrecordid>eNqFkM1v1DAQxS0EKkvhyg0pB4Tg4MUfsZ0cyxYKqJRKXQkJhCzHnqgu-cJOSnPiX8c0q0UcEKeRZn7vzcxD6DEla0oIe3k1xDWThKicMkrvoBUVjGBJqLqLVglgmIu8vI8exHhFCJFEiAN0kJNC0VKt0M_zKfgOsiM728bb7GyyDfTRO4jrTOJj38J4OTem9V2PS_zlOcPDJXSp05jutu96THGcqjj6cRrB4STob-YXi_DrcOsfMxOzjemcd2ZM27rRX_tgmvgQ3atTgUe7eoi2b15vN2_x6ceTd5ujU2xzISm2gklZgLCyVKwwDigljgtaACcVVVVeMy4Ic5WFWpWCm9pKqZQ0ZU0pdfwQPVtsh9B_nyCOuvXRQpOegH6KWklRMCV5AtcLaEMfY4BaD8G3JsyaEv07cJ0C138CT4InO-epasHt8V3Caf50NzfRmqYOprM-7rGCEE6oSFi5YD98A_N_lur35xd_nYAXrY8j3Oy1JnzTUnEl9KezE_3qA_t8vBUXepP4YuEhBX7tIehoPXQWnA9gR-16_69vfwHZFLyH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76582763</pqid></control><display><type>article</type><title>Purine Acyclic Nucleosides. 6-Dimethylamino-9-[(2-phenylalanylamido-1-substituted-ethoxy)methyl]purines as Candidate Antivirals</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Kelley, James L. ; Selway, J.W.T. ; Schaeffer, Howard J.</creator><creatorcontrib>Kelley, James L. ; Selway, J.W.T. ; Schaeffer, Howard J.</creatorcontrib><description>Several acyclic puromycin analogues containing hydrocarbon substituents on the 1′-position of the aminoethoxymethyl moiety were synthesized and tested for antiviral activity. The N-carbobenzoxy intermediate 7c was active in vitro against Mengo and Semliki Forest viruses.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600741211</identifier><identifier>PMID: 4087197</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Antiviral Agents - chemical synthesis ; Antiviral Agents - pharmacology ; Biological and medical sciences ; Chemical Phenomena ; Chemistry ; General pharmacology ; Humans ; Magnetic Resonance Spectroscopy ; Medical sciences ; Pharmacology. Drug treatments ; Physicochemical properties. Structure-activity relationships ; Purines - chemical synthesis ; Purines - pharmacology ; Puromycin - analogs & derivatives ; Puromycin - chemical synthesis ; Puromycin - pharmacology ; Viruses - drug effects</subject><ispartof>Journal of pharmaceutical sciences, 1985-12, Vol.74 (12), p.1302-1304</ispartof><rights>1985 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1985 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4561-c52668e5c69728ade110d3518e30b17b4f23502dbcef7953afc66776a9f111d3</citedby><cites>FETCH-LOGICAL-c4561-c52668e5c69728ade110d3518e30b17b4f23502dbcef7953afc66776a9f111d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600741211$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600741211$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8003015$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4087197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelley, James L.</creatorcontrib><creatorcontrib>Selway, J.W.T.</creatorcontrib><creatorcontrib>Schaeffer, Howard J.</creatorcontrib><title>Purine Acyclic Nucleosides. 6-Dimethylamino-9-[(2-phenylalanylamido-1-substituted-ethoxy)methyl]purines as Candidate Antivirals</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Several acyclic puromycin analogues containing hydrocarbon substituents on the 1′-position of the aminoethoxymethyl moiety were synthesized and tested for antiviral activity. The N-carbobenzoxy intermediate 7c was active in vitro against Mengo and Semliki Forest viruses.</description><subject>Antiviral Agents - chemical synthesis</subject><subject>Antiviral Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemical properties. Structure-activity relationships</subject><subject>Purines - chemical synthesis</subject><subject>Purines - pharmacology</subject><subject>Puromycin - analogs & derivatives</subject><subject>Puromycin - chemical synthesis</subject><subject>Puromycin - pharmacology</subject><subject>Viruses - drug effects</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1v1DAQxS0EKkvhyg0pB4Tg4MUfsZ0cyxYKqJRKXQkJhCzHnqgu-cJOSnPiX8c0q0UcEKeRZn7vzcxD6DEla0oIe3k1xDWThKicMkrvoBUVjGBJqLqLVglgmIu8vI8exHhFCJFEiAN0kJNC0VKt0M_zKfgOsiM728bb7GyyDfTRO4jrTOJj38J4OTem9V2PS_zlOcPDJXSp05jutu96THGcqjj6cRrB4STob-YXi_DrcOsfMxOzjemcd2ZM27rRX_tgmvgQ3atTgUe7eoi2b15vN2_x6ceTd5ujU2xzISm2gklZgLCyVKwwDigljgtaACcVVVVeMy4Ic5WFWpWCm9pKqZQ0ZU0pdfwQPVtsh9B_nyCOuvXRQpOegH6KWklRMCV5AtcLaEMfY4BaD8G3JsyaEv07cJ0C138CT4InO-epasHt8V3Caf50NzfRmqYOprM-7rGCEE6oSFi5YD98A_N_lur35xd_nYAXrY8j3Oy1JnzTUnEl9KezE_3qA_t8vBUXepP4YuEhBX7tIehoPXQWnA9gR-16_69vfwHZFLyH</recordid><startdate>198512</startdate><enddate>198512</enddate><creator>Kelley, James L.</creator><creator>Selway, J.W.T.</creator><creator>Schaeffer, Howard J.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198512</creationdate><title>Purine Acyclic Nucleosides. 6-Dimethylamino-9-[(2-phenylalanylamido-1-substituted-ethoxy)methyl]purines as Candidate Antivirals</title><author>Kelley, James L. ; Selway, J.W.T. ; Schaeffer, Howard J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4561-c52668e5c69728ade110d3518e30b17b4f23502dbcef7953afc66776a9f111d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Antiviral Agents - chemical synthesis</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemical properties. Structure-activity relationships</topic><topic>Purines - chemical synthesis</topic><topic>Purines - pharmacology</topic><topic>Puromycin - analogs & derivatives</topic><topic>Puromycin - chemical synthesis</topic><topic>Puromycin - pharmacology</topic><topic>Viruses - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelley, James L.</creatorcontrib><creatorcontrib>Selway, J.W.T.</creatorcontrib><creatorcontrib>Schaeffer, Howard J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelley, James L.</au><au>Selway, J.W.T.</au><au>Schaeffer, Howard J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Purine Acyclic Nucleosides. 6-Dimethylamino-9-[(2-phenylalanylamido-1-substituted-ethoxy)methyl]purines as Candidate Antivirals</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1985-12</date><risdate>1985</risdate><volume>74</volume><issue>12</issue><spage>1302</spage><epage>1304</epage><pages>1302-1304</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>Several acyclic puromycin analogues containing hydrocarbon substituents on the 1′-position of the aminoethoxymethyl moiety were synthesized and tested for antiviral activity. The N-carbobenzoxy intermediate 7c was active in vitro against Mengo and Semliki Forest viruses.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>4087197</pmid><doi>10.1002/jps.2600741211</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1985-12, Vol.74 (12), p.1302-1304 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76582763 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Biological and medical sciences Chemical Phenomena Chemistry General pharmacology Humans Magnetic Resonance Spectroscopy Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Purines - chemical synthesis Purines - pharmacology Puromycin - analogs & derivatives Puromycin - chemical synthesis Puromycin - pharmacology Viruses - drug effects |
| title | Purine Acyclic Nucleosides. 6-Dimethylamino-9-[(2-phenylalanylamido-1-substituted-ethoxy)methyl]purines as Candidate Antivirals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T07%3A54%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Purine%20Acyclic%20Nucleosides.%206-Dimethylamino-9-%5B(2-phenylalanylamido-1-substituted-ethoxy)methyl%5Dpurines%20as%20Candidate%20Antivirals&rft.jtitle=Journal%20of%20pharmaceutical%20sciences&rft.au=Kelley,%20James%20L.&rft.date=1985-12&rft.volume=74&rft.issue=12&rft.spage=1302&rft.epage=1304&rft.pages=1302-1304&rft.issn=0022-3549&rft.eissn=1520-6017&rft.coden=JPMSAE&rft_id=info:doi/10.1002/jps.2600741211&rft_dat=%3Cproquest_cross%3E76582763%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76582763&rft_id=info:pmid/4087197&rft_els_id=S0022354915469709&rfr_iscdi=true |