Purine Acyclic Nucleosides. 6-Dimethylamino-9-[(2-phenylalanylamido-1-substituted-ethoxy)methyl]purines as Candidate Antivirals

Several acyclic puromycin analogues containing hydrocarbon substituents on the 1′-position of the aminoethoxymethyl moiety were synthesized and tested for antiviral activity. The N-carbobenzoxy intermediate 7c was active in vitro against Mengo and Semliki Forest viruses.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1985-12, Vol.74 (12), p.1302-1304
Hauptverfasser:	Kelley, James L., Selway, J.W.T., Schaeffer, Howard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Biological and medical sciences Chemical Phenomena Chemistry General pharmacology Humans Magnetic Resonance Spectroscopy Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Purines - chemical synthesis Purines - pharmacology Puromycin - analogs & derivatives Puromycin - chemical synthesis Puromycin - pharmacology Viruses - drug effects
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Beschreibung
Zusammenfassung:	Several acyclic puromycin analogues containing hydrocarbon substituents on the 1′-position of the aminoethoxymethyl moiety were synthesized and tested for antiviral activity. The N-carbobenzoxy intermediate 7c was active in vitro against Mengo and Semliki Forest viruses.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600741211