Cretinism after weekly dosing with levothyroxine for treatment of congenital hypothyroidism

Cretinism after weekly dosing with levothyroxine for treatment of congenital hypothyroidism

An 11-month-old infant was treated elsewhere for congenital hypothyroidism with weekly doses of levothyroxine. The infant had cardinal features of cretinism including poor growth, delayed skeletal maturation, and mental retardation. Treatment of such infants with weekly doses of levothyroxine cannot...

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Veröffentlicht in:The Journal of pediatrics 1994-07, Vol.125 (1), p.147-149
Hauptverfasser: Rivkees, Scott A., Hardin, Dana S.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Bronchiolitis Obliterans - etiology
Congenital Hypothyroidism - etiology
Drug Administration Schedule
Endocrinopathies
Fatal Outcome
Female
Humans
Hypothyroidism - complications
Hypothyroidism - drug therapy
Infant
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Thyroid. Thyroid axis (diseases)
Thyroxine - administration & dosage
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Zusammenfassung:An 11-month-old infant was treated elsewhere for congenital hypothyroidism with weekly doses of levothyroxine. The infant had cardinal features of cretinism including poor growth, delayed skeletal maturation, and mental retardation. Treatment of such infants with weekly doses of levothyroxine cannot be justified. (J P EDIATR 1994;125:147-9)
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(94)70142-3