Resistance to Murine Acquired Immunodeficiency Syndrome (MAIDS)

Research indicates that the change in the pattern of cytokine helper T cells from TH1 to TH2 phenotype may not cause immune suppression seen in MAIDS. Genetic factors could be involved in the immune response to the murine retrovirus in mice.

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1994-07, Vol.265 (5169), p.264-267
Hauptverfasser:	Gilmore, Gary L., Morawetz, Renate A., Doherty, T. Mark, Giese, Nathalia A., Hartley, Janet W., Müller, Werner, Kühn, Ralf, Rajewsky, Klaus, Coffman, Robert, Morse, Herbert C., Kanagawa, Osami, Vaupel, Barbara A., Gayama, Shinyo, Koehler, Georges, Kipf, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Biological resistance Cytokines Cytokines - genetics Cytokines - immunology Disease resistance Disease Susceptibility Genetic aspects Genetic loci Immunity, Innate - genetics Immunogenetics Immunologic deficiency syndromes Immunological deficiency syndromes Infections Interleukin-4 - deficiency Interleukin-4 - genetics Interleukin-4 - immunology Medical genetics Mice Mice, Inbred Strains Mice, Mutant Strains Mice, Transgenic Murine Acquired Immunodeficiency Syndrome - genetics Murine Acquired Immunodeficiency Syndrome - immunology Spleen cells T-Lymphocytes, Helper-Inducer - immunology Technical Comments Viral diseases Viruses
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Beschreibung
Zusammenfassung:	Research indicates that the change in the pattern of cytokine helper T cells from TH1 to TH2 phenotype may not cause immune suppression seen in MAIDS. Genetic factors could be involved in the immune response to the murine retrovirus in mice.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.8023146