Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus Oxyacantha (Hawthorn) flower heads

A hydro-alcoholic extract from Crataegus o. (Co) flower heads inhibited thromboxane A2 (TXA2) biosynthesis in vitro. This present study aims to find out which are the active principles. The main components, as revealed by chromatography, were tested. We also took into consideration catechin and epic...

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Veröffentlicht in:	Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 1994-04, Vol.50 (4), p.173-175
Hauptverfasser:	VIBES, J, LASSERRE, B, GLEYE, J, DECLUME, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apigenin Biological and medical sciences Blood Platelets - ultrastructure Catechin - pharmacology Flavonoids - pharmacology General pharmacology Horses Hydrolysis Medical sciences Microsomes - enzymology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plants, Medicinal Quercetin - analogs & derivatives Quercetin - pharmacology Thromboxane A2 - antagonists & inhibitors Thromboxane A2 - biosynthesis
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Zusammenfassung:	A hydro-alcoholic extract from Crataegus o. (Co) flower heads inhibited thromboxane A2 (TXA2) biosynthesis in vitro. This present study aims to find out which are the active principles. The main components, as revealed by chromatography, were tested. We also took into consideration catechin and epicatechin: although they do not appear as such with chromatography because of their polymerisation or-and condensed structure, these two proanthocyanidins seem to play a major role in the mentioned activity of the plant.
ISSN:	0952-3278 1532-2823
DOI:	10.1016/0952-3278(94)90141-4