Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier
KUMANO, N., SUZUKI, S., OIZUMI, K., KONNO, K., HIMORI, T., MITACHI, Y. and WAKUI, A. Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier. Tohoku J. exp. Med., 1985, 147 (2), 125-133-The peripheral T lymphocyte subsets and natural killer...
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| Veröffentlicht in: | The Tohoku Journal of Experimental Medicine 1985, Vol.147(2), pp.125-133 |
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| container_title | The Tohoku Journal of Experimental Medicine |
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| creator | KUMANO, NOBUKO SUZUKI, SHUJI OIZUMI, KOTARO KONNO, KIYOSHI HIMORI, TATSUMI MITACHI, YASUSHI WAKUI, AKIRA |
| description | KUMANO, N., SUZUKI, S., OIZUMI, K., KONNO, K., HIMORI, T., MITACHI, Y. and WAKUI, A. Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier. Tohoku J. exp. Med., 1985, 147 (2), 125-133-The peripheral T lymphocyte subsets and natural killer (NK) cells of patients with cancer were studied by monoclonal antibody assays in comparison with those of non-cancer individuals. An imbalance of immunoregulatory T cell subsets was frequently found in the group of cancer patients (n=26), being characterized by a relatively high proportion of OKT8+ cells (45.0± 12.0%, p |
| doi_str_mv | 10.1620/tjem.147.125 |
| format | Article |
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Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier. Tohoku J. exp. Med., 1985, 147 (2), 125-133-The peripheral T lymphocyte subsets and natural killer (NK) cells of patients with cancer were studied by monoclonal antibody assays in comparison with those of non-cancer individuals. An imbalance of immunoregulatory T cell subsets was frequently found in the group of cancer patients (n=26), being characterized by a relatively high proportion of OKT8+ cells (45.0± 12.0%, p<0.01) and a low OKT4+/OKT8+ ratio (1.29±0.56, p<0.05). T cell level showed no significant difference as assessed by either OKT3 or rosette formation with sheep erythrocytes (E). The effect of bestatin was examined in 10 of these cancer patients. The relative proportion of T cell subsets tended to normalize 2 to 6 weeks after starting the daily doses of 30mg per body. The mean percentage of OKT8+ cells decreased from 47.2 to 33.4 (p<0.01), while the helper to suppressor ratio increased from 1.18 to 1.79 (p<0.01). A significant increase was also found in the percentage and number of OKT4+ cells and HNK-1+ cells after the drug administration, while T cell level tended to converge to a normal range.</description><identifier>ISSN: 0040-8727</identifier><identifier>EISSN: 1349-3329</identifier><identifier>DOI: 10.1620/tjem.147.125</identifier><identifier>PMID: 3909512</identifier><language>eng</language><publisher>Japan: Tohoku University Medical Press</publisher><subject>Adjuvants, Immunologic - pharmacology ; Aged ; Antibodies, Monoclonal ; bestatin ; Female ; Fluorescent Antibody Technique ; Homeostasis ; Humans ; immunorestorative effect ; Leucine - analogs & derivatives ; Leucine - pharmacology ; Male ; Middle Aged ; Neoplasms - immunology ; T cell subsets ; T-Lymphocytes - classification ; T-Lymphocytes - drug effects</subject><ispartof>The Tohoku Journal of Experimental Medicine, 1985, Vol.147(2), pp.125-133</ispartof><rights>Tohoku University Medical Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-d80d1e04ed2b51ac65604ffc12dd63dd41c24a09feb917988eed2d2e8085047b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3909512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUMANO, NOBUKO</creatorcontrib><creatorcontrib>SUZUKI, SHUJI</creatorcontrib><creatorcontrib>OIZUMI, KOTARO</creatorcontrib><creatorcontrib>KONNO, KIYOSHI</creatorcontrib><creatorcontrib>HIMORI, TATSUMI</creatorcontrib><creatorcontrib>MITACHI, YASUSHI</creatorcontrib><creatorcontrib>WAKUI, AKIRA</creatorcontrib><title>Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier</title><title>The Tohoku Journal of Experimental Medicine</title><addtitle>Tohoku J. Exp. Med.</addtitle><description>KUMANO, N., SUZUKI, S., OIZUMI, K., KONNO, K., HIMORI, T., MITACHI, Y. and WAKUI, A. Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier. Tohoku J. exp. Med., 1985, 147 (2), 125-133-The peripheral T lymphocyte subsets and natural killer (NK) cells of patients with cancer were studied by monoclonal antibody assays in comparison with those of non-cancer individuals. An imbalance of immunoregulatory T cell subsets was frequently found in the group of cancer patients (n=26), being characterized by a relatively high proportion of OKT8+ cells (45.0± 12.0%, p<0.01) and a low OKT4+/OKT8+ ratio (1.29±0.56, p<0.05). T cell level showed no significant difference as assessed by either OKT3 or rosette formation with sheep erythrocytes (E). The effect of bestatin was examined in 10 of these cancer patients. The relative proportion of T cell subsets tended to normalize 2 to 6 weeks after starting the daily doses of 30mg per body. The mean percentage of OKT8+ cells decreased from 47.2 to 33.4 (p<0.01), while the helper to suppressor ratio increased from 1.18 to 1.79 (p<0.01). A significant increase was also found in the percentage and number of OKT4+ cells and HNK-1+ cells after the drug administration, while T cell level tended to converge to a normal range.</description><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Aged</subject><subject>Antibodies, Monoclonal</subject><subject>bestatin</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>immunorestorative effect</subject><subject>Leucine - analogs & derivatives</subject><subject>Leucine - pharmacology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms - immunology</subject><subject>T cell subsets</subject><subject>T-Lymphocytes - classification</subject><subject>T-Lymphocytes - drug effects</subject><issn>0040-8727</issn><issn>1349-3329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1v2zAQxYmiheO43boW4NTJcvkpUWNiNIkBBy2QdBYo8lTLECmHlBDkvy9lO1678MB7Pz4c7yH0lZIVzRn5MezBragoVpTJD2hOuSgzzln5Ec0JESRTBSuu0HWMe0K4IEU-QzNeklJSNkdx42rdaW8A9w1-xmvoOvw01hGGiFuP15MU8G89tOBTS3uLN6k-9rZtWpPavcev7bDDtxCHdPVLrPGT08nmse_AjJ0OeOPc6Ht3fAPhM_rU6C7Cl3NdoD93P5_XD9n21_1mfbPNjFBiyKwilgIRYFktqTa5zIloGkOZtTm3VlDDhCZlA3VJi1IpSKRloIiSRBQ1X6DvJ99D6F_GNF7l2mjSB7WHfoxVkUspeS7-C1IhmFBqApcn0IQ-xgBNdQit0-GtoqSawqimMBJfVCmMhH87-461A3uBz9tP-t1J36fV_YWLrsPQmg6OZrRMrpMhez-ZvABmp0MFnv8DUlWehA</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>KUMANO, NOBUKO</creator><creator>SUZUKI, SHUJI</creator><creator>OIZUMI, KOTARO</creator><creator>KONNO, KIYOSHI</creator><creator>HIMORI, TATSUMI</creator><creator>MITACHI, YASUSHI</creator><creator>WAKUI, AKIRA</creator><general>Tohoku University Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19850101</creationdate><title>Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier</title><author>KUMANO, NOBUKO ; SUZUKI, SHUJI ; OIZUMI, KOTARO ; KONNO, KIYOSHI ; HIMORI, TATSUMI ; MITACHI, YASUSHI ; WAKUI, AKIRA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-d80d1e04ed2b51ac65604ffc12dd63dd41c24a09feb917988eed2d2e8085047b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Aged</topic><topic>Antibodies, Monoclonal</topic><topic>bestatin</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>immunorestorative effect</topic><topic>Leucine - analogs & derivatives</topic><topic>Leucine - pharmacology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms - immunology</topic><topic>T cell subsets</topic><topic>T-Lymphocytes - classification</topic><topic>T-Lymphocytes - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUMANO, NOBUKO</creatorcontrib><creatorcontrib>SUZUKI, SHUJI</creatorcontrib><creatorcontrib>OIZUMI, KOTARO</creatorcontrib><creatorcontrib>KONNO, KIYOSHI</creatorcontrib><creatorcontrib>HIMORI, TATSUMI</creatorcontrib><creatorcontrib>MITACHI, YASUSHI</creatorcontrib><creatorcontrib>WAKUI, AKIRA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Tohoku Journal of Experimental Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUMANO, NOBUKO</au><au>SUZUKI, SHUJI</au><au>OIZUMI, KOTARO</au><au>KONNO, KIYOSHI</au><au>HIMORI, TATSUMI</au><au>MITACHI, YASUSHI</au><au>WAKUI, AKIRA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier</atitle><jtitle>The Tohoku Journal of Experimental Medicine</jtitle><addtitle>Tohoku J. Exp. Med.</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>147</volume><issue>2</issue><spage>125</spage><epage>133</epage><pages>125-133</pages><issn>0040-8727</issn><eissn>1349-3329</eissn><abstract>KUMANO, N., SUZUKI, S., OIZUMI, K., KONNO, K., HIMORI, T., MITACHI, Y. and WAKUI, A. Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier. Tohoku J. exp. Med., 1985, 147 (2), 125-133-The peripheral T lymphocyte subsets and natural killer (NK) cells of patients with cancer were studied by monoclonal antibody assays in comparison with those of non-cancer individuals. An imbalance of immunoregulatory T cell subsets was frequently found in the group of cancer patients (n=26), being characterized by a relatively high proportion of OKT8+ cells (45.0± 12.0%, p<0.01) and a low OKT4+/OKT8+ ratio (1.29±0.56, p<0.05). T cell level showed no significant difference as assessed by either OKT3 or rosette formation with sheep erythrocytes (E). The effect of bestatin was examined in 10 of these cancer patients. The relative proportion of T cell subsets tended to normalize 2 to 6 weeks after starting the daily doses of 30mg per body. The mean percentage of OKT8+ cells decreased from 47.2 to 33.4 (p<0.01), while the helper to suppressor ratio increased from 1.18 to 1.79 (p<0.01). A significant increase was also found in the percentage and number of OKT4+ cells and HNK-1+ cells after the drug administration, while T cell level tended to converge to a normal range.</abstract><cop>Japan</cop><pub>Tohoku University Medical Press</pub><pmid>3909512</pmid><doi>10.1620/tjem.147.125</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adjuvants, Immunologic - pharmacology Aged Antibodies, Monoclonal bestatin Female Fluorescent Antibody Technique Homeostasis Humans immunorestorative effect Leucine - analogs & derivatives Leucine - pharmacology Male Middle Aged Neoplasms - immunology T cell subsets T-Lymphocytes - classification T-Lymphocytes - drug effects |
| title | Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier |
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