Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier

Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier

KUMANO, N., SUZUKI, S., OIZUMI, K., KONNO, K., HIMORI, T., MITACHI, Y. and WAKUI, A. Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier. Tohoku J. exp. Med., 1985, 147 (2), 125-133-The peripheral T lymphocyte subsets and natural killer...

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Veröffentlicht in:The Tohoku Journal of Experimental Medicine 1985, Vol.147(2), pp.125-133
Hauptverfasser: KUMANO, NOBUKO, SUZUKI, SHUJI, OIZUMI, KOTARO, KONNO, KIYOSHI, HIMORI, TATSUMI, MITACHI, YASUSHI, WAKUI, AKIRA
Format: Artikel
Sprache:eng
Schlagworte:
Adjuvants, Immunologic - pharmacology
Aged
Antibodies, Monoclonal
bestatin
Female
Fluorescent Antibody Technique
Homeostasis
Humans
immunorestorative effect
Leucine - analogs & derivatives
Leucine - pharmacology
Male
Middle Aged
Neoplasms - immunology
T cell subsets
T-Lymphocytes - classification
T-Lymphocytes - drug effects
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Zusammenfassung:KUMANO, N., SUZUKI, S., OIZUMI, K., KONNO, K., HIMORI, T., MITACHI, Y. and WAKUI, A. Imbalance of T Cell Subsets in Cancer Patients and Its Modification with Bestatin, a Small Molecular Immunomodifier. Tohoku J. exp. Med., 1985, 147 (2), 125-133-The peripheral T lymphocyte subsets and natural killer (NK) cells of patients with cancer were studied by monoclonal antibody assays in comparison with those of non-cancer individuals. An imbalance of immunoregulatory T cell subsets was frequently found in the group of cancer patients (n=26), being characterized by a relatively high proportion of OKT8+ cells (45.0± 12.0%, p
ISSN:0040-8727
1349-3329
DOI:10.1620/tjem.147.125