Theophylline reduces the response to nasal challenge with antigen

Theophylline reduces the response to nasal challenge with antigen

A nasal challenge model of allergic rhinitis was used to determine if pretreatment with oral theophylline reduces histamine release in vivo. Ten subjects were entered into a double-blind, cross-over trial. The results showed that both the physiologic response (sneezing) (p = 0.02) and the amount of...

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Veröffentlicht in:The American journal of medicine 1985-12, Vol.79 (6), p.43-47
Hauptverfasser: Naclerio, Robert M., Bartenfelder, Denise, Proud, David, Togias, Alkis G., Meyers, Deborah A., Kagey-Sobotka, Anne, Norman, Philip S., Lichtenstein, Lawrence M.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Bronchial Provocation Tests
Double-Blind Method
Female
Histamine Release - drug effects
Humans
Kinins - analysis
Male
Peptide Hydrolases - analysis
Rhinitis - physiopathology
Sneezing - drug effects
Theophylline - pharmacology
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Zusammenfassung:A nasal challenge model of allergic rhinitis was used to determine if pretreatment with oral theophylline reduces histamine release in vivo. Ten subjects were entered into a double-blind, cross-over trial. The results showed that both the physiologic response (sneezing) (p = 0.02) and the amount of mediators (histamine, kinins, toluene sulfonyl arginine methyl ester esterase activity) (p
ISSN:0002-9343
1555-7162
DOI:10.1016/0002-9343(85)90087-7