Synthesis of 4-Alkoxyaryl β-D-Glucopyranosides and Their Inhibitory Effects on Histamine Release from Rat Peritoneal Mast Cells Induced by Concanavalin A

The inhibitory effects of newly synthesized 4-alkoxyaryl β-D-glucopyranosides on histamine release from rat peritoneal mast cells induced by concanavalin A were examined. A plot of hydrophobicity (k') against inhibitory activity of the compounds showed a distinct maximum, and 4-decyloxy-2, 3, 6...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1994/03/15, Vol.42(3), pp.570-575
Hauptverfasser:	WANG, Tzer Chuan, FURUKAWA, Haruhiro, NIHRO, Yasunori, KAKEGAWA, Hisao, MATSUMOTO, Hitoshi, SATOH, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	4-alkoxyaryl β-D-glucopyranoside 4-decyloxy-2, 3, 6-trimethylphenyl β-D-glucopyranoside Animals Chemistry Concanavalin A - antagonists & inhibitors Concanavalin A - pharmacology Exact sciences and technology Glucosides - chemical synthesis Glucosides - pharmacology Histamine Release - drug effects histamine release inhibition In Vitro Techniques Male Mast Cells - drug effects Mast Cells - metabolism Noncondensed benzenic compounds Organic chemistry Peritoneal Cavity - cytology Preparations and properties Rats Rats, Sprague-Dawley β-glucosidase
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Zusammenfassung:	The inhibitory effects of newly synthesized 4-alkoxyaryl β-D-glucopyranosides on histamine release from rat peritoneal mast cells induced by concanavalin A were examined. A plot of hydrophobicity (k') against inhibitory activity of the compounds showed a distinct maximum, and 4-decyloxy-2, 3, 6-trimethylphenyl β-D-glucopyranoside was the most potent inhibitor among the tested compounds.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.42.570