A D1 agonist in the MPOA facilitates copulation in male rats

The classic dopamine agonist apomorphine, microinjected into the medial preoptic area (MPOA), enhances the copulatory behavior of male rats, while pharmacological blockade of endogenous dopamine inhibits sexual behavior. We now report that MPOA injections of 10 micrograms of the selective D1 agonist...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1994-03, Vol.47 (3), p.483-486
Hauptverfasser:	MARKOWSKI, V. P, EATON, R. C, LUMLEY, L. A, MOSES, J, HULL, E. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apomorphine - administration & dosage Apomorphine - pharmacology Behavioral psychophysiology Benzazepines - administration & dosage Benzazepines - pharmacology Biological and medical sciences Copulation - drug effects Dopamine Agents - administration & dosage Dopamine Agents - pharmacology Ejaculation - drug effects Female Fundamental and applied biological sciences. Psychology Injections Male Neurotransmission and behavior Ovariectomy Penile Erection - drug effects Preoptic Area - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyridines - pharmacology Rats Receptors, Dopamine D1 - drug effects Stimulation, Chemical
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Zusammenfassung:	The classic dopamine agonist apomorphine, microinjected into the medial preoptic area (MPOA), enhances the copulatory behavior of male rats, while pharmacological blockade of endogenous dopamine inhibits sexual behavior. We now report that MPOA injections of 10 micrograms of the selective D1 agonist dihydroxyphenyl-tetrahydrothienopyridine (THP) significantly increased the number of ejaculations, while decreasing the latency to ejaculate in a 30-min test. These effects were not observed following coadministration of the selective D1 antagonist SCH-23390 with 10 micrograms THP. This enhancement may be related to a D1-stimulated facilitation of penile erections.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(94)90147-3