The Nitric Oxide-Scavenging Properties of Ginkgo Biloba Extract EGb 761

Ginkgo biloba extract EGb 761 was found to be a scavenger of nitric oxide in in vitro acellular systems, under physiological conditions. EGb 761 competed with oxyhemoglobin for reaction with nitric oxide generated during the interaction Complex I of catalase. An EGb 761 dose-dependent decrease in th...

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Veröffentlicht in:	Biochemical and biophysical research communications 1994-06, Vol.201 (2), p.748-755
Hauptverfasser:	Marcocci, L., Maguire, J.J., Droylefaix, M.T., Packer, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalase - metabolism Cattle Free Radical Scavengers Ginkgo biloba Glucose Oxidase - metabolism Kinetics Nitric Oxide - chemistry Nitrites - analysis Nitroprusside - chemistry Oxyhemoglobins - chemistry Oxyhemoglobins - metabolism Plant Extracts - chemistry Plant Extracts - pharmacology
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Beschreibung
Zusammenfassung:	Ginkgo biloba extract EGb 761 was found to be a scavenger of nitric oxide in in vitro acellular systems, under physiological conditions. EGb 761 competed with oxyhemoglobin for reaction with nitric oxide generated during the interaction Complex I of catalase. An EGb 761 dose-dependent decrease in the amount of nitrite formed in the reaction of oxygen with nitric oxide produced from solution of 5mM sodium nitroprusside was also observed. These data implicate it as a potential therapeutic agent in conditions of altered production of nitric oxide.
ISSN:	0006-291X 1090-2104
DOI:	10.1006/bbrc.1994.1764