Renal nerve activity during Bezold-Jarisch reflex in cats

The purpose of this study was to evaluate the roles of arterial and cardiopulmonary baroreflexes in mediating the renal efferent nerve activity during BezoldoJarisch reflex in anesthetized cats, With cardiopulmonary and arterial baroreflexes intact, administration of intravenous veratrine (30 pg/kg) resulted in decreases in arterial pressure, heart rate and renal nerve activity. After selective vagotomy, intravenous veratrine resulted in decreases in renal nerve activity, but reductions in blood pressure and heart rate were markedly attenuated. After sinoaortic denervation and vagotomy, intravenous veratrine resulted in increases in blood pressure and renal nerve activity. These results suggest that a decrease in renal nerve activity during intravenous veratrine is mediated by both cardiopulmonary receptors with vagal afferents and high pressure baroreceptorse.