Augmentation of mitogen-induced proliferative responses by in vitro indomethacin in patients with acquired immune deficiency syndrome and aids-related complex

Augmentation of mitogen-induced proliferative responses by in vitro indomethacin in patients with acquired immune deficiency syndrome and aids-related complex

The effect of indomethacin on mitogen-induced lymphocyte proliferative responses was studied in six normal heterosexual subjects and nine patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC). Indomethacin enhanced only Con A-induced lymphocyte responses in six...

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Veröffentlicht in:International journal of immunopharmacology 1985, Vol.7 (6), p.917-921
Hauptverfasser: Reddy, Mohan M., Manvar, Dolly, Ahuja, Kishore K., Moriarty, Mary L., Grieco, Michael H.
Format: Artikel
Sprache:eng
Schlagworte:
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - immunology
Adjuvants, Immunologic
Adult
AIDS/HIV
Biological and medical sciences
Concanavalin A - pharmacology
Humans
Immunomodulators
In Vitro Techniques
Indomethacin - pharmacology
Lymphocyte Activation - drug effects
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Phytohemagglutinins - pharmacology
Pokeweed Mitogens - pharmacology
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Zusammenfassung:The effect of indomethacin on mitogen-induced lymphocyte proliferative responses was studied in six normal heterosexual subjects and nine patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC). Indomethacin enhanced only Con A-induced lymphocyte responses in six heterosexual men. In contrast, study of the cells from AIDS and ARC revealed that indomethacin enhanced PHA-induced lymphocyte proliferative responses from 52,600 counts/min to 70,900 counts/min ( P
ISSN:0192-0561
1879-3495
DOI:10.1016/0192-0561(85)90055-4