Differential distribution of amyloid protein precursor immunoreactivity in the rat brain studied by using five different antibodies

The β‐amyloid or A4 protein is found deposited in neuritic plaques and neurofibrillary tangles in Alzheimer's disease (AD) affected brains and in the brains of adults with Down's Syndrome. The precursor to this 42 amino acid protein is the 695 amino acid long amyloid protein precursor (APP...

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Veröffentlicht in:	Journal of comparative neurology (1911) 1994-04, Vol.342 (1), p.78-96
Hauptverfasser:	Beeson, James G., Shelton, Earl R., Chan, Hardy W., Gage, Fred H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-Protein Precursor - immunology Amyloid beta-Protein Precursor - metabolism Animals Antibodies - immunology Antibody Specificity APP Biochemistry and metabolism Biological and medical sciences Blotting, Western Brain Chemistry - physiology Brain Mapping Central nervous system CHO Cells Cricetinae Electrophoresis, Polyacrylamide Gel Female Fundamental and applied biological sciences. Psychology Immunohistochemistry Nerve Endings - immunology Nerve Endings - ultrastructure Nerve Tissue Proteins - immunology Nerve Tissue Proteins - isolation & purification Peptide Fragments - immunology Rats Rats, Inbred F344 Rats, Sprague-Dawley Vertebrates: nervous system and sense organs β-amyloid
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