In-vitro susceptibility of mycobacteria to ciprofloxacin

Two hundred and seventy-six strains of mycobacteria were tested for susceptibility to ciprofloxacin (Bay 0 9867), a 4-quinolone antimicrobial agent. Most strains of Mycobacterium tuberculosis, Myco. fortuitum, Myco. kansasii, Myco. marinum and Myco. xenopi were sensitive to minimum inhibitory concen...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1985-11, Vol.16 (5), p.575-580
Hauptverfasser:	Collins, C. H., Uttley, Anne H. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Ciprofloxacin Culture Media Drug Resistance, Microbial Medical sciences Microbial Sensitivity Tests Mycobacterium Mycobacterium - drug effects Mycobacterium Infections - microbiology Mycobacterium tuberculosis - drug effects Pharmacology. Drug treatments Quinolines - pharmacology
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Zusammenfassung:	Two hundred and seventy-six strains of mycobacteria were tested for susceptibility to ciprofloxacin (Bay 0 9867), a 4-quinolone antimicrobial agent. Most strains of Mycobacterium tuberculosis, Myco. fortuitum, Myco. kansasii, Myco. marinum and Myco. xenopi were sensitive to minimum inhibitory concentrations (MICs) of 0·78–1·56 mg/l, equivalent to resistance ratios of 1 or 2. Most strains of Myco. avium-intracellulare and Myco. chelonei required MICs of 12·5 mg/l or more, giving resistance ratios of 8.
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/16.5.575