Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers

Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers

A single-centre, open, Phase I-study comparison of the pharmacokinetics of a single dose of metaclazepam 10 mg, a new 1,4-benzodiazepine has been done in 10 older and 20 younger volunteers. No important age-related effect was found on the kinetics of metaclazepam or its N-desmethyl derivative, the p...

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Veröffentlicht in:European journal of clinical pharmacology 1985-01, Vol.29 (2), p.247-249
Hauptverfasser: MOLZ, K.-H, GIELSDORF, W, RASPER, J, JAEGER, H, HAUSLEITER, H. J, ACHTERT, G, PHILIPP, P
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age Factors
Aged
Anti-Anxiety Agents
Benzodiazepines - blood
Benzodiazepines - metabolism
Biological and medical sciences
Biotransformation
Female
Humans
Kinetics
Male
Medical sciences
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
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Beschreibung
Zusammenfassung:A single-centre, open, Phase I-study comparison of the pharmacokinetics of a single dose of metaclazepam 10 mg, a new 1,4-benzodiazepine has been done in 10 older and 20 younger volunteers. No important age-related effect was found on the kinetics of metaclazepam or its N-desmethyl derivative, the principal metabolite in man.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00547431