Characterization and autoradiographic distribution of neurotensin binding sites in the human brain

The characteristics and topographical distribution of monoiodo 125I-Tyr 3-neurotensin (NT) binding sites in normal human brain tissue were studied on brain sections and by quantitative autoradiography. Sections at the level of the substantia nigra show a dissociation constant and maximal binding cap...

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Veröffentlicht in:	Brain research 1985-12, Vol.348 (2), p.375-380
Hauptverfasser:	Sarrieau, A., Javoy-Agid, F., Kitabgi, P., Dussaillant, M., Vial, M., Vincent, J.P., Agid, Y., Rostène, W.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Autoradiography Binding Sites Biological and medical sciences Brain - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - metabolism Corpus Striatum - metabolism dopamine Dopamine - physiology Fundamental and applied biological sciences. Psychology human brain Humans Hypothalamus - metabolism monoiodinated neuropeptide neurotensin Neurotensin - metabolism Nucleus Accumbens - metabolism receptor autoradiography Vertebrates: nervous system and sense organs
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Zusammenfassung:	The characteristics and topographical distribution of monoiodo 125I-Tyr 3-neurotensin (NT) binding sites in normal human brain tissue were studied on brain sections and by quantitative autoradiography. Sections at the level of the substantia nigra show a dissociation constant and maximal binding capacity of4.8 ± 0.8nM and 70 ± 7fmol/mg protein, respectively. High density of 125I-NT binding sites were mainly found in dopaminergic (DA)-rich areas such as the substantia nigra, the ventral tegmental area, the striatum and the nucleus accumbens, further supporting an interaction between NT and DA neurons in human brain.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(85)90461-5