Effect of phenytoin on [ 3H]norepinephrine release from synaptosomes

Phenytoin reduces depolarization-linked [ 3H]norepinephrine release from rat brain synaptosomes. When choline chloride was substituted for NaCl the phenytoin effect was attenuated but still significant. This is consistent with the theory that phenytoin reduces both Na and Ca influx during depolariza...

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Veröffentlicht in:	Brain research 1985-12, Vol.348 (2), p.387-390
Hauptverfasser:	Pincus, Jonathan H., Weinfeld, Henry M.
Format:	Artikel
Sprache:	eng
Schlagworte:	[ 3H]norepinephrine release Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain - metabolism Buffers choline chloride Male Medical sciences Membrane Potentials - drug effects Neuropharmacology Norepinephrine - metabolism Pharmacology. Drug treatments phenytoin Phenytoin - pharmacology Potassium Chloride - pharmacology Rats Rats, Inbred Strains Sodium - pharmacology sodium chloride synaptosome Synaptosomes - metabolism
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Zusammenfassung:	Phenytoin reduces depolarization-linked [ 3H]norepinephrine release from rat brain synaptosomes. When choline chloride was substituted for NaCl the phenytoin effect was attenuated but still significant. This is consistent with the theory that phenytoin reduces both Na and Ca influx during depolarization.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(85)90463-9