Can immunohistological analysis of transbronchial biopsy specimens predict responder status in early acute rejection of lung allografts?
Acute cellular rejection (ACR) in the early posttransplant period is recognized as one predictor of the development of bronchiolitis obliterans in lung transplant recipients. Using an immunohistochemical panel of antibodies to CD3, L26, HLA-DR, collagenase IV, proliferating cell nuclear antigen (PCN...
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| Veröffentlicht in: | Human pathology 1994-05, Vol.25 (5), p.525-529 |
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| creator | Yousem, Samuel A. Martin, Thomas Paradis, Irvin L. Keenan, Robert Griffith, Bartley P. |
| description | Acute cellular rejection (ACR) in the early posttransplant period is recognized as one predictor of the development of bronchiolitis obliterans in lung transplant recipients. Using an immunohistochemical panel of antibodies to CD3, L26, HLA-DR, collagenase IV, proliferating cell nuclear antigen (PCNA), KPI, and S100 antigens we analyzed cases of moderate ACR that did respond (n = 11) and that did not respond (n = 10) to bolus solumedrol therapy early in the postoperative period ( |
| doi_str_mv | 10.1016/0046-8177(94)90126-0 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76519663</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0046817794901260</els_id><sourcerecordid>76519663</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-e9a7618feb35a6518bdcd5a5d2b36ec27cacb2d2e7e8e3651126f4017757e783</originalsourceid><addsrcrecordid>eNp9kM2KFDEUhYMoYzv6BgpZiOiiNKmq_NRGkcY_GHAz-5BK3ZrJkErK3JTQb-Bjm7abXrrK4nzn3PAR8pKz95xx-YGxXjaaK_V26N8NjLeyYY_IjouubXQ3tI_J7oI8Jc8QHxjjXPTiilzpljHZ6x35s7eR-mXZYrr3WFJId97ZQG204YAeaZppyTbimFN0975Go08rHiiu4PwCEemaYfKu0Ay4pjhBplhs2ZD6SMHmcKDWbQVq_gCu-BSPo2GLd9SGei_bueCn5-TJbAPCi_N7TW6_frndf29ufn77sf9807hOy9LAYJXkeoaxE1YKrsfJTcKKqR07Ca5VzrqxnVpQoKGrQNUy96wqEAqU7q7Jm9PsmtOvDbCYxaODEGyEtKFRtTJI2VWwP4EuJ8QMs1mzX2w-GM7M0b85yjVHuWbozT__htXaq_P-Ni4wXUpn4TV_fc4tVs9zVes8XrCeSzFoVbGPJwyqit8eskHnIboqOleHZkr-___4C-KwpSA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76519663</pqid></control><display><type>article</type><title>Can immunohistological analysis of transbronchial biopsy specimens predict responder status in early acute rejection of lung allografts?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Yousem, Samuel A. ; Martin, Thomas ; Paradis, Irvin L. ; Keenan, Robert ; Griffith, Bartley P.</creator><creatorcontrib>Yousem, Samuel A. ; Martin, Thomas ; Paradis, Irvin L. ; Keenan, Robert ; Griffith, Bartley P.</creatorcontrib><description>Acute cellular rejection (ACR) in the early posttransplant period is recognized as one predictor of the development of bronchiolitis obliterans in lung transplant recipients. Using an immunohistochemical panel of antibodies to CD3, L26, HLA-DR, collagenase IV, proliferating cell nuclear antigen (PCNA), KPI, and S100 antigens we analyzed cases of moderate ACR that did respond (n = 11) and that did not respond (n = 10) to bolus solumedrol therapy early in the postoperative period (<100 days) to determine if we could identify predictors of histological response. Responders who had follow-up negative biopsies after therapy had biopsy specimens containing an average of 41.1% T cells (range, 15.1 to 69.8), 8.8% B cells (range, 0.6 to 20), 18.1% HLA-DR-positive cells (range, 3 to 29.6), 12.2% PCNA-positive cells (range, 2.7 to 22.6), 8.9% collagenase IV-positive cells (range, 0.7 to 20.9), and rare dendritic cells. Nonresponders who had follow-up biopsies that failed to show a significant change in rejection grade had biopsy specimens with the following average cell profiles: 35.8% T cells (range, 7 to 70.7), 21.6% B cells (range, 3.7 to 39.5), 14.2% HLA-DR-positive cells (range, 1.8 to 24.7), 11.4% PCNA-positive cells (range, 0.8 to 22), 12.6% collagenase IV-positive cells (range, 0.6 to 34.1), and occasional dendritic cells. Statistical analysis suggested that large numbers of B lymphocytes in early acute rejection predicts nonresponsiveness to interventional immunosuppressive therapy and may indicate a significant role of humoral rejection in the behavior of early allograft rejection.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/0046-8177(94)90126-0</identifier><identifier>PMID: 8200648</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Antibodies, Monoclonal ; antibody-mediated rejection ; B cell ; Biological and medical sciences ; Biopsy - methods ; Bronchiolitis Obliterans - prevention & control ; General pharmacology ; Graft Rejection - drug therapy ; Graft Rejection - pathology ; Humans ; humoral rejection ; Immunophenotyping ; lung ; Lung Transplantation - immunology ; Lung Transplantation - pathology ; Medical sciences ; Methylprednisolone Hemisuccinate - therapeutic use ; Miscellaneous ; Pharmacology. Drug treatments ; Prognosis ; rejection ; T cell ; transplantation ; Transplantation, Homologous - immunology</subject><ispartof>Human pathology, 1994-05, Vol.25 (5), p.525-529</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-e9a7618feb35a6518bdcd5a5d2b36ec27cacb2d2e7e8e3651126f4017757e783</citedby><cites>FETCH-LOGICAL-c386t-e9a7618feb35a6518bdcd5a5d2b36ec27cacb2d2e7e8e3651126f4017757e783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0046-8177(94)90126-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4165987$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8200648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yousem, Samuel A.</creatorcontrib><creatorcontrib>Martin, Thomas</creatorcontrib><creatorcontrib>Paradis, Irvin L.</creatorcontrib><creatorcontrib>Keenan, Robert</creatorcontrib><creatorcontrib>Griffith, Bartley P.</creatorcontrib><title>Can immunohistological analysis of transbronchial biopsy specimens predict responder status in early acute rejection of lung allografts?</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Acute cellular rejection (ACR) in the early posttransplant period is recognized as one predictor of the development of bronchiolitis obliterans in lung transplant recipients. Using an immunohistochemical panel of antibodies to CD3, L26, HLA-DR, collagenase IV, proliferating cell nuclear antigen (PCNA), KPI, and S100 antigens we analyzed cases of moderate ACR that did respond (n = 11) and that did not respond (n = 10) to bolus solumedrol therapy early in the postoperative period (<100 days) to determine if we could identify predictors of histological response. Responders who had follow-up negative biopsies after therapy had biopsy specimens containing an average of 41.1% T cells (range, 15.1 to 69.8), 8.8% B cells (range, 0.6 to 20), 18.1% HLA-DR-positive cells (range, 3 to 29.6), 12.2% PCNA-positive cells (range, 2.7 to 22.6), 8.9% collagenase IV-positive cells (range, 0.7 to 20.9), and rare dendritic cells. Nonresponders who had follow-up biopsies that failed to show a significant change in rejection grade had biopsy specimens with the following average cell profiles: 35.8% T cells (range, 7 to 70.7), 21.6% B cells (range, 3.7 to 39.5), 14.2% HLA-DR-positive cells (range, 1.8 to 24.7), 11.4% PCNA-positive cells (range, 0.8 to 22), 12.6% collagenase IV-positive cells (range, 0.6 to 34.1), and occasional dendritic cells. Statistical analysis suggested that large numbers of B lymphocytes in early acute rejection predicts nonresponsiveness to interventional immunosuppressive therapy and may indicate a significant role of humoral rejection in the behavior of early allograft rejection.</description><subject>Antibodies, Monoclonal</subject><subject>antibody-mediated rejection</subject><subject>B cell</subject><subject>Biological and medical sciences</subject><subject>Biopsy - methods</subject><subject>Bronchiolitis Obliterans - prevention & control</subject><subject>General pharmacology</subject><subject>Graft Rejection - drug therapy</subject><subject>Graft Rejection - pathology</subject><subject>Humans</subject><subject>humoral rejection</subject><subject>Immunophenotyping</subject><subject>lung</subject><subject>Lung Transplantation - immunology</subject><subject>Lung Transplantation - pathology</subject><subject>Medical sciences</subject><subject>Methylprednisolone Hemisuccinate - therapeutic use</subject><subject>Miscellaneous</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>rejection</subject><subject>T cell</subject><subject>transplantation</subject><subject>Transplantation, Homologous - immunology</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2KFDEUhYMoYzv6BgpZiOiiNKmq_NRGkcY_GHAz-5BK3ZrJkErK3JTQb-Bjm7abXrrK4nzn3PAR8pKz95xx-YGxXjaaK_V26N8NjLeyYY_IjouubXQ3tI_J7oI8Jc8QHxjjXPTiilzpljHZ6x35s7eR-mXZYrr3WFJId97ZQG204YAeaZppyTbimFN0975Go08rHiiu4PwCEemaYfKu0Ay4pjhBplhs2ZD6SMHmcKDWbQVq_gCu-BSPo2GLd9SGei_bueCn5-TJbAPCi_N7TW6_frndf29ufn77sf9807hOy9LAYJXkeoaxE1YKrsfJTcKKqR07Ca5VzrqxnVpQoKGrQNUy96wqEAqU7q7Jm9PsmtOvDbCYxaODEGyEtKFRtTJI2VWwP4EuJ8QMs1mzX2w-GM7M0b85yjVHuWbozT__htXaq_P-Ni4wXUpn4TV_fc4tVs9zVes8XrCeSzFoVbGPJwyqit8eskHnIboqOleHZkr-___4C-KwpSA</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Yousem, Samuel A.</creator><creator>Martin, Thomas</creator><creator>Paradis, Irvin L.</creator><creator>Keenan, Robert</creator><creator>Griffith, Bartley P.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940501</creationdate><title>Can immunohistological analysis of transbronchial biopsy specimens predict responder status in early acute rejection of lung allografts?</title><author>Yousem, Samuel A. ; Martin, Thomas ; Paradis, Irvin L. ; Keenan, Robert ; Griffith, Bartley P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-e9a7618feb35a6518bdcd5a5d2b36ec27cacb2d2e7e8e3651126f4017757e783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Antibodies, Monoclonal</topic><topic>antibody-mediated rejection</topic><topic>B cell</topic><topic>Biological and medical sciences</topic><topic>Biopsy - methods</topic><topic>Bronchiolitis Obliterans - prevention & control</topic><topic>General pharmacology</topic><topic>Graft Rejection - drug therapy</topic><topic>Graft Rejection - pathology</topic><topic>Humans</topic><topic>humoral rejection</topic><topic>Immunophenotyping</topic><topic>lung</topic><topic>Lung Transplantation - immunology</topic><topic>Lung Transplantation - pathology</topic><topic>Medical sciences</topic><topic>Methylprednisolone Hemisuccinate - therapeutic use</topic><topic>Miscellaneous</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>rejection</topic><topic>T cell</topic><topic>transplantation</topic><topic>Transplantation, Homologous - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yousem, Samuel A.</creatorcontrib><creatorcontrib>Martin, Thomas</creatorcontrib><creatorcontrib>Paradis, Irvin L.</creatorcontrib><creatorcontrib>Keenan, Robert</creatorcontrib><creatorcontrib>Griffith, Bartley P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yousem, Samuel A.</au><au>Martin, Thomas</au><au>Paradis, Irvin L.</au><au>Keenan, Robert</au><au>Griffith, Bartley P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can immunohistological analysis of transbronchial biopsy specimens predict responder status in early acute rejection of lung allografts?</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>25</volume><issue>5</issue><spage>525</spage><epage>529</epage><pages>525-529</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Acute cellular rejection (ACR) in the early posttransplant period is recognized as one predictor of the development of bronchiolitis obliterans in lung transplant recipients. Using an immunohistochemical panel of antibodies to CD3, L26, HLA-DR, collagenase IV, proliferating cell nuclear antigen (PCNA), KPI, and S100 antigens we analyzed cases of moderate ACR that did respond (n = 11) and that did not respond (n = 10) to bolus solumedrol therapy early in the postoperative period (<100 days) to determine if we could identify predictors of histological response. Responders who had follow-up negative biopsies after therapy had biopsy specimens containing an average of 41.1% T cells (range, 15.1 to 69.8), 8.8% B cells (range, 0.6 to 20), 18.1% HLA-DR-positive cells (range, 3 to 29.6), 12.2% PCNA-positive cells (range, 2.7 to 22.6), 8.9% collagenase IV-positive cells (range, 0.7 to 20.9), and rare dendritic cells. Nonresponders who had follow-up biopsies that failed to show a significant change in rejection grade had biopsy specimens with the following average cell profiles: 35.8% T cells (range, 7 to 70.7), 21.6% B cells (range, 3.7 to 39.5), 14.2% HLA-DR-positive cells (range, 1.8 to 24.7), 11.4% PCNA-positive cells (range, 0.8 to 22), 12.6% collagenase IV-positive cells (range, 0.6 to 34.1), and occasional dendritic cells. Statistical analysis suggested that large numbers of B lymphocytes in early acute rejection predicts nonresponsiveness to interventional immunosuppressive therapy and may indicate a significant role of humoral rejection in the behavior of early allograft rejection.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8200648</pmid><doi>10.1016/0046-8177(94)90126-0</doi><tpages>5</tpages></addata></record> |
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| ispartof | Human pathology, 1994-05, Vol.25 (5), p.525-529 |
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| subjects | Antibodies, Monoclonal antibody-mediated rejection B cell Biological and medical sciences Biopsy - methods Bronchiolitis Obliterans - prevention & control General pharmacology Graft Rejection - drug therapy Graft Rejection - pathology Humans humoral rejection Immunophenotyping lung Lung Transplantation - immunology Lung Transplantation - pathology Medical sciences Methylprednisolone Hemisuccinate - therapeutic use Miscellaneous Pharmacology. Drug treatments Prognosis rejection T cell transplantation Transplantation, Homologous - immunology |
| title | Can immunohistological analysis of transbronchial biopsy specimens predict responder status in early acute rejection of lung allografts? |
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