Can immunohistological analysis of transbronchial biopsy specimens predict responder status in early acute rejection of lung allografts?

Acute cellular rejection (ACR) in the early posttransplant period is recognized as one predictor of the development of bronchiolitis obliterans in lung transplant recipients. Using an immunohistochemical panel of antibodies to CD3, L26, HLA-DR, collagenase IV, proliferating cell nuclear antigen (PCN...

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Veröffentlicht in:	Human pathology 1994-05, Vol.25 (5), p.525-529
Hauptverfasser:	Yousem, Samuel A., Martin, Thomas, Paradis, Irvin L., Keenan, Robert, Griffith, Bartley P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal antibody-mediated rejection B cell Biological and medical sciences Biopsy - methods Bronchiolitis Obliterans - prevention & control General pharmacology Graft Rejection - drug therapy Graft Rejection - pathology Humans humoral rejection Immunophenotyping lung Lung Transplantation - immunology Lung Transplantation - pathology Medical sciences Methylprednisolone Hemisuccinate - therapeutic use Miscellaneous Pharmacology. Drug treatments Prognosis rejection T cell transplantation Transplantation, Homologous - immunology
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Zusammenfassung:	Acute cellular rejection (ACR) in the early posttransplant period is recognized as one predictor of the development of bronchiolitis obliterans in lung transplant recipients. Using an immunohistochemical panel of antibodies to CD3, L26, HLA-DR, collagenase IV, proliferating cell nuclear antigen (PCNA), KPI, and S100 antigens we analyzed cases of moderate ACR that did respond (n = 11) and that did not respond (n = 10) to bolus solumedrol therapy early in the postoperative period (
ISSN:	0046-8177 1532-8392
DOI:	10.1016/0046-8177(94)90126-0