Cerebral uptake and retention of 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HM-PAO)

A new radiopharmaceutical, Tc-hexamethylpropyleneamine oxime (Tc-HM-PAO) is described. This agent displays considerable promise for imaging cerebral blood flow. In studies in rats and one human volunteer, Tc-HM-PAO demonstrates good brain uptake, prolonged retention of activity in the brain, and slo...

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Veröffentlicht in:	Nuclear medicine communications 1985-08, Vol.6 (8), p.443-448
Hauptverfasser:	HOLMES, R A, CHAPLIN, S B, ROYSTON, K G, HOFFMAN, T J, VOLKERT, W A, NOWOTNIK, D P, CANNING, L R, CUMMING, S A, HARRISON, R C, HIGLEY, B, NECHVATAL, G, PICKETT, R D, PIPER, I M, NEIRINCKX, R D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Brain - diagnostic imaging Cerebral Cortex - diagnostic imaging Cerebrovascular Circulation Humans Oximes Rats Rats, Inbred Strains Technetium Technetium Tc 99m Exametazime Thalamic Nuclei - diagnostic imaging Tomography, Emission-Computed - methods
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Zusammenfassung:	A new radiopharmaceutical, Tc-hexamethylpropyleneamine oxime (Tc-HM-PAO) is described. This agent displays considerable promise for imaging cerebral blood flow. In studies in rats and one human volunteer, Tc-HM-PAO demonstrates good brain uptake, prolonged retention of activity in the brain, and slow regional redistribution. These properties suggest that this new radiopharmaceutical is ideal for single photon emission tomographic (SPECT) imaging of cerebral blood flow.
ISSN:	0143-3636
DOI:	10.1097/00006231-198508000-00003