Protein tyrosine phosphatases: characterization of extracellular and intracellular domains

Protein tyrosine phosphatases (PTPs) play an important role in the regulation of cell growth and differentiation. With over 30 PTPs identified, the specific functions of these enzymes are now being addressed. The identification of extracellular domain receptor-like PTP interactions and the character...

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Veröffentlicht in:	Current opinion in genetics & development 1994-02, Vol.4 (1), p.31-39
Hauptverfasser:	Mourey, Robert J., Dixon, Jack E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Carbonic Anhydrases - metabolism Cell Adhesion Molecules - metabolism Cell Nucleus - enzymology Endoplasmic Reticulum - enzymology Extracellular Space - enzymology Humans Intracellular Fluid - enzymology Leukocyte Common Antigens - metabolism Molecular Sequence Data Molecular Structure Protein Tyrosine Phosphatases - chemistry Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Subcellular Fractions - enzymology
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Beschreibung
Zusammenfassung:	Protein tyrosine phosphatases (PTPs) play an important role in the regulation of cell growth and differentiation. With over 30 PTPs identified, the specific functions of these enzymes are now being addressed. The identification of extracellular domain receptor-like PTP interactions and the characterization of intracellular PTP ‘targeting’ domains represent recent efforts in this pursuit.
ISSN:	0959-437X 1879-0380
DOI:	10.1016/0959-437X(94)90088-4