Antinociceptive and other opioid effects of a new series of dermorphin analogues after subcutaneous administration in the rat

Antinociceptive and other opioid effects of a new series of dermorphin analogues after subcutaneous administration in the rat

A series of hepta-, hexa-, penta- and tetrapeptide analogues of dermorphin have been evaluated in the rat for antinociceptive activity after subcutaneous (SC) administration at the screening dose of 4 mg/kg. Effective doses (ED 50) were calculated for the most active compounds. Presence of spontaneo...

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Veröffentlicht in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1985-05, Vol.6 (3), p.433-437
Hauptverfasser: Cervini, M.A., Rossi, A.C., Perseo, G., De Castiglione, R.
Format: Artikel
Sprache:eng
Schlagworte:
Akinesia
Amino Acid Sequence
Analgesia
Animals
Biological and medical sciences
Corneal reflex
Defecation
Defecation - drug effects
Dermorphin analogues
Fundamental and applied biological sciences. Psychology
Injections, Subcutaneous
Male
Micturition
Molecular Weight
Movement - drug effects
Narcotics - pharmacology
Oligopeptides - chemical synthesis
Oligopeptides - pharmacology
Opioid Peptides
Pain - drug therapy
Rat
Rats
Rats, Inbred Strains
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Structure-Activity Relationship
Subcutaneous administration
Synthetic peptides
Urination - drug effects
Vertebrates: nervous system and sense organs
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Zusammenfassung:A series of hepta-, hexa-, penta- and tetrapeptide analogues of dermorphin have been evaluated in the rat for antinociceptive activity after subcutaneous (SC) administration at the screening dose of 4 mg/kg. Effective doses (ED 50) were calculated for the most active compounds. Presence of spontaneous movements, defecation, micturition and corneal reflex were also recorded. Syntheses and analytical data of new derivatives are briefly reported.
ISSN:0196-9781
1873-5169
DOI:10.1016/0196-9781(85)90109-3