Effect of Captopril on Heavy Proteinuria in Azotemic Diabetics

We investigated whether captopril, an angiotensin-converting-enzyme inhibitor, would reduce proteinuria in patients with advanced diabetic nephropathy. Captopril (37.5 mg given in divided doses three times daily) was administered to 10 azotemic diabetics with heavy proteinuria. Urinary protein decre...

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Veröffentlicht in:	The New England journal of medicine 1985-12, Vol.313 (26), p.1617-1620
Hauptverfasser:	Taguma, Yoshio, Kitamoto, Yasunori, Futaki, Gen, Ueda, Hitoshi, Monma, Hiromichi, Ishizaki, Makoto, Takahashi, Hisashi, Sekino, Hiroshi, Sasaki, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angiotensin-converting enzyme inhibitors Biological and medical sciences Blood Glucose - analysis Blood levels Blood pressure Blood Pressure - drug effects Captopril - administration & dosage Captopril - therapeutic use Creatinine Creatinine - blood Diabetes mellitus Diabetic Nephropathies - complications Diabetic Nephropathies - drug therapy Excretion Female General and cellular metabolism. Vitamins Humans Hypertension, Renal - drug therapy Male Medical sciences Middle Aged Nephropathy Peptidyl-dipeptidase A Pharmacology. Drug treatments Potassium - blood Proteinuria Proteinuria - drug therapy Proteinuria - etiology Proteinuria - urine Uremia - drug therapy Uremia - etiology
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Zusammenfassung:	We investigated whether captopril, an angiotensin-converting-enzyme inhibitor, would reduce proteinuria in patients with advanced diabetic nephropathy. Captopril (37.5 mg given in divided doses three times daily) was administered to 10 azotemic diabetics with heavy proteinuria. Urinary protein decreased promptly within two weeks (from 10.6±2.2 to 6.1±1.4 g per day [mean ±S.E.M.]; P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198512263132601