Serum antibodies to klebsiella capsular polysaccharides in ankylosing spondylitis

Objective. To measure antibodies to Klebsiella capsular polysaccharides in the sera of HLA–B27 positive patients with ankylosing spondylitis (AS), compared with HLA–B27 positive and HLA–B27 negative healthy control subjects. Methods. Antibodies were detected by means of an enzyme‐linked immunosorben...

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Veröffentlicht in:	Arthritis and rheumatism 1994-05, Vol.37 (5), p.754-759
Hauptverfasser:	Sahly, Hany, Podschun, Rainer, Sass, Rainer, Bröker, Barbara, Kekow, Jörn, Gross, Wolfgang Ludwig, Ullmann, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Anti-Idiotypic - analysis Antibodies, Bacterial - analysis Bacterial Capsules - immunology Biological and medical sciences Diseases of the osteoarticular system Enzyme-Linked Immunosorbent Assay Female Humans Immunoglobulin G - immunology Inflammatory joint diseases Klebsiella - chemistry Klebsiella - immunology Male Medical sciences Middle Aged Polysaccharides, Bacterial - immunology Spondylitis, Ankylosing - immunology
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Zusammenfassung:	Objective. To measure antibodies to Klebsiella capsular polysaccharides in the sera of HLA–B27 positive patients with ankylosing spondylitis (AS), compared with HLA–B27 positive and HLA–B27 negative healthy control subjects. Methods. Antibodies were detected by means of an enzyme‐linked immunosorbent assay specific for each of the 77 known Klebsiella serotypes. Results. Significantly elevated frequencies and titers of antibodies to capsular polysaccharides K26, K36, and K50 were detected in sera from AS patients, compared with controls. Conclusion. These results suggest the predominance of Klebsiella serotypes K26, K36, and K50 in patients with AS.
ISSN:	0004-3591 1529-0131
DOI:	10.1002/art.1780370521