Conserved Linkage of Early Growth Response 4, Annexin 4, and Transforming Growth Factor α on Mouse Chromosome 6

The mouse genes encoding early growth response 4 (Egr4), annexin IV (Anx4), and transforming growth factor a (Tgfa) have been mapped to a linkage group on mouse chromosome 6 that is conserved on human chromosome 2p11-p13. The genes are closely linked, with 0/215 recombinants between Anx4 and Tgfa an...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1994-01, Vol.19 (2), p.388-390
Hauptverfasser:	Barrow, Lon L., Simin, Karl, Jones, Julie M., Lee, David C., Meisler, Miriam H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A4 - genetics Biological and medical sciences Chromosome Mapping Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Genes Genetic Linkage Genetics of eukaryotes. Biological and molecular evolution Humans Mice - genetics Neuromuscular Diseases - genetics Recombination, Genetic Transcription Factors - genetics Transforming Growth Factor alpha - genetics Vertebrata Zinc Fingers
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Beschreibung
Zusammenfassung:	The mouse genes encoding early growth response 4 (Egr4), annexin IV (Anx4), and transforming growth factor a (Tgfa) have been mapped to a linkage group on mouse chromosome 6 that is conserved on human chromosome 2p11-p13. The genes are closely linked, with 0/215 recombinants between Anx4 and Tgfa and 1/215 recombinants between these genes and Egr4 . The genes are located approximately 2 cM distal to mnd2, a mouse mutation causing neuromuscular disease. The results demonstrate that mnd2 is located at an internal position within this conserved linkage group.
ISSN:	0888-7543 1089-8646
DOI:	10.1006/geno.1994.1078