Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: Pediatric perspective and natural history

We studied the syndrome of acanthosis nigricans, obesity, insulin resistance, and hyperandrogenemia in 22 patients. Although isolated case reports in adolescents have appeared, this syndrome has not received full recognition as a pediatric entity. Our patients (17 girls, five boys) had a mean weight...

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Veröffentlicht in:The Journal of pediatrics 1985-12, Vol.107 (6), p.893-897
Hauptverfasser: Richards, Gail E., Cavallo, Anita, Meyer, Walter J., Prince, Melvin J., Peters, Edward J., Stuart, Charles A., Smith, Edward R.
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Sprache:eng
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Zusammenfassung:We studied the syndrome of acanthosis nigricans, obesity, insulin resistance, and hyperandrogenemia in 22 patients. Although isolated case reports in adolescents have appeared, this syndrome has not received full recognition as a pediatric entity. Our patients (17 girls, five boys) had a mean weight 5.7 SD above the mean for age, although mean height was only 0.5 SD above the mean for age. All patients had acanthosis nigricans. Their insulin resistance was significantly greater than that in a control group with comparable obesity. Fasting insulin concentration was 5.25 μU/ml in lean controls, 19.6 μU/ml in obese controls, and 49.8 μU/ml in study patients (P
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(85)80182-7