Synthesis of 15O-labeled butanol via organoborane chemistry
Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O 2− 15O with tri- n-butylborane and tri- sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical...
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| Veröffentlicht in: | The International journal of applied radiation and isotopes 1985-11, Vol.36 (11), p.853-855 |
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| container_end_page | 855 |
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| container_issue | 11 |
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| container_title | The International journal of applied radiation and isotopes |
| container_volume | 36 |
| creator | Kabalka, G.W. Lambrecht, R.M. Sajjad, M. Fowler, J.S. Kunda, S.A. McCollum, G.W. MacGregor, R. |
| description | Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O
2−
15O with tri-
n-butylborane and tri-
sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of
15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET. |
| doi_str_mv | 10.1016/0020-708X(85)90017-1 |
| format | Article |
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2−
15O with tri-
n-butylborane and tri-
sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of
15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.</description><identifier>ISSN: 0020-708X</identifier><identifier>DOI: 10.1016/0020-708X(85)90017-1</identifier><identifier>PMID: 4066058</identifier><identifier>CODEN: ARISEF</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Aliphatic compounds ; Boranes ; Butanols ; Chemistry ; Chromatography, High Pressure Liquid ; Exact sciences and technology ; Indicators and Reagents ; Isotope Labeling - methods ; Organic chemistry ; Oxygen Isotopes ; Preparations and properties</subject><ispartof>The International journal of applied radiation and isotopes, 1985-11, Vol.36 (11), p.853-855</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2998-5f5dce5d7ad92231315cef9037c99e327f9d980b3db23c5cae9e18fea0b69e7e3</citedby><cites>FETCH-LOGICAL-c2998-5f5dce5d7ad92231315cef9037c99e327f9d980b3db23c5cae9e18fea0b69e7e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8444980$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4066058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kabalka, G.W.</creatorcontrib><creatorcontrib>Lambrecht, R.M.</creatorcontrib><creatorcontrib>Sajjad, M.</creatorcontrib><creatorcontrib>Fowler, J.S.</creatorcontrib><creatorcontrib>Kunda, S.A.</creatorcontrib><creatorcontrib>McCollum, G.W.</creatorcontrib><creatorcontrib>MacGregor, R.</creatorcontrib><title>Synthesis of 15O-labeled butanol via organoborane chemistry</title><title>The International journal of applied radiation and isotopes</title><addtitle>Int J Appl Radiat Isot</addtitle><description>Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O
2−
15O with tri-
n-butylborane and tri-
sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of
15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.</description><subject>Aliphatic compounds</subject><subject>Boranes</subject><subject>Butanols</subject><subject>Chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Exact sciences and technology</subject><subject>Indicators and Reagents</subject><subject>Isotope Labeling - methods</subject><subject>Organic chemistry</subject><subject>Oxygen Isotopes</subject><subject>Preparations and properties</subject><issn>0020-708X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhnOhzDn9Bwq9ENGLatI0TYIgyPALBrtQwbuQJqcu0rUzaQf792au7NKrfJznnPPyIHRG8A3BpLjFOMMpx-LzSrBriTHhKTlA4_33EToO4Ts-M1mIERrluCgwE2N097ZpugUEF5K2Sgibp7UuoQablH2nm7ZO1k4nrf-K97L1uoHELGDpQuc3J-iw0nWA0-GcoI-nx_fpSzqbP79OH2apyaQUKauYNcAs11ZmGSWUMAOVxJQbKYFmvJJWClxSW2bUMKNBAhEVaFwWEjjQCbrczV359qeH0Km430BdxzRtHxQvcsGxpBHMd6DxbQgeKrXybqn9RhGstp7UVojaClGCqT9PisS282F-Xy7B7psGSbF-MdR1MLquogXjwh4TeZ7H_BG732EQXawdeBWMg8aAdR5Mp2zr_s_xC9-nhdg</recordid><startdate>198511</startdate><enddate>198511</enddate><creator>Kabalka, G.W.</creator><creator>Lambrecht, R.M.</creator><creator>Sajjad, M.</creator><creator>Fowler, J.S.</creator><creator>Kunda, S.A.</creator><creator>McCollum, G.W.</creator><creator>MacGregor, R.</creator><general>Elsevier B.V</general><general>Pergamon Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198511</creationdate><title>Synthesis of 15O-labeled butanol via organoborane chemistry</title><author>Kabalka, G.W. ; Lambrecht, R.M. ; Sajjad, M. ; Fowler, J.S. ; Kunda, S.A. ; McCollum, G.W. ; MacGregor, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2998-5f5dce5d7ad92231315cef9037c99e327f9d980b3db23c5cae9e18fea0b69e7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Aliphatic compounds</topic><topic>Boranes</topic><topic>Butanols</topic><topic>Chemistry</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Exact sciences and technology</topic><topic>Indicators and Reagents</topic><topic>Isotope Labeling - methods</topic><topic>Organic chemistry</topic><topic>Oxygen Isotopes</topic><topic>Preparations and properties</topic><toplevel>online_resources</toplevel><creatorcontrib>Kabalka, G.W.</creatorcontrib><creatorcontrib>Lambrecht, R.M.</creatorcontrib><creatorcontrib>Sajjad, M.</creatorcontrib><creatorcontrib>Fowler, J.S.</creatorcontrib><creatorcontrib>Kunda, S.A.</creatorcontrib><creatorcontrib>McCollum, G.W.</creatorcontrib><creatorcontrib>MacGregor, R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kabalka, G.W.</au><au>Lambrecht, R.M.</au><au>Sajjad, M.</au><au>Fowler, J.S.</au><au>Kunda, S.A.</au><au>McCollum, G.W.</au><au>MacGregor, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of 15O-labeled butanol via organoborane chemistry</atitle><jtitle>The International journal of applied radiation and isotopes</jtitle><addtitle>Int J Appl Radiat Isot</addtitle><date>1985-11</date><risdate>1985</risdate><volume>36</volume><issue>11</issue><spage>853</spage><epage>855</epage><pages>853-855</pages><issn>0020-708X</issn><coden>ARISEF</coden><abstract>Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O
2−
15O with tri-
n-butylborane and tri-
sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of
15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>4066058</pmid><doi>10.1016/0020-708X(85)90017-1</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-708X |
| ispartof | The International journal of applied radiation and isotopes, 1985-11, Vol.36 (11), p.853-855 |
| issn | 0020-708X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aliphatic compounds Boranes Butanols Chemistry Chromatography, High Pressure Liquid Exact sciences and technology Indicators and Reagents Isotope Labeling - methods Organic chemistry Oxygen Isotopes Preparations and properties |
| title | Synthesis of 15O-labeled butanol via organoborane chemistry |
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