Synthesis of 15O-labeled butanol via organoborane chemistry

Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O 2− 15O with tri- n-butylborane and tri- sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical...

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Veröffentlicht in:	The International journal of applied radiation and isotopes 1985-11, Vol.36 (11), p.853-855
Hauptverfasser:	Kabalka, G.W., Lambrecht, R.M., Sajjad, M., Fowler, J.S., Kunda, S.A., McCollum, G.W., MacGregor, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Boranes Butanols Chemistry Chromatography, High Pressure Liquid Exact sciences and technology Indicators and Reagents Isotope Labeling - methods Organic chemistry Oxygen Isotopes Preparations and properties
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Zusammenfassung:	Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O 2− 15O with tri- n-butylborane and tri- sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of 15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.
ISSN:	0020-708X
DOI:	10.1016/0020-708X(85)90017-1