Evaluation of (o)-[ 77Br]bromohippuran as renal tubular function agent

( o)-[ 77Br]bromohippuran (BHIP) was developed as renal tubular function agent due to its favourable chemical and physical properties and compared to ( o)-[ 131I]iodohippuran (IHIP). Renograms obtained from baboons were compared and absorbed radiation dose calculations performed. Although BHIP showe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The International journal of applied radiation and isotopes 1985-09, Vol.36 (9), p.727-732
Hauptverfasser:	van Aswegen, A., Van Wyk, A.J., Roodt, J.P., Pieters, H., Herbst, C.P., Otto, A.C., Lötter, M.G., Haasbroek, F.J., Minnaar, P.C., Fourie, P.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bromine Evaluation Studies as Topic Functional Laterality Fundamental and applied biological sciences. Psychology Iodohippuric Acid - analogs & derivatives Kidney - physiology Kidney Function Tests Kidney Tubules - diagnostic imaging Papio Radioisotopes Radionuclide Imaging Tissue Distribution Urinary Bladder - diagnostic imaging Vertebrates: urinary system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	( o)-[ 77Br]bromohippuran (BHIP) was developed as renal tubular function agent due to its favourable chemical and physical properties and compared to ( o)-[ 131I]iodohippuran (IHIP). Renograms obtained from baboons were compared and absorbed radiation dose calculations performed. Although BHIP showed a delayed kidney uptake and washout pattern, good kidney clearance of the radionuclide was obtained after 30 min. Radiation dose values for BHIP were markedly lower than for IHIP indicating that larger activities of BHIP could be administered to increase counting statistics. BHIP imaging in normal volunteers did however not substantiate the favourable behaviour obtained in the primate.
ISSN:	0020-708X
DOI:	10.1016/0020-708X(85)90044-4