Cloning of a T Cell Growth Factor That Interacts with the β Chain of the Interleukin-2 Receptor

A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties w...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1994-05, Vol.264 (5161), p.965-968
Hauptverfasser:	Grabstein, Kenneth H., Eisenman, June, Shanebeck, Kurt, Rauch, Charles, Srinivasan, Subhashini, Fung, Victor, Beers, Courtney, Richardson, Jane, Schoenborn, Michael A., Ahdieh, Minoo, Johnson, Lisabeth, Alderson, Mark R., Watson, James D., Anderson, Dirk M., Giri, Judith G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analysis of the immune response. Humoral and cellular immunity Animals Antibodies B lymphocytes Biological and medical sciences Cell differentiation Cell lines Cells, Cultured Cloning, Molecular Complementary DNA Cultured cells Cytokines Differentiation Drug receptors Fundamental and applied biological sciences. Psychology Fundamental immunology Haplorhini Humans Immunobiology Interleukin-15 Interleukin-2 Interleukin-2 - immunology Interleukin-2 - metabolism Interleukin-2 - pharmacology Interleukins - chemistry Interleukins - genetics Interleukins - metabolism Interleukins - pharmacology Killer Cells, Lymphokine-Activated - immunology Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphokines, interleukins ( function, expression) Messenger RNA Molecular Sequence Data Protein Structure, Secondary Receptors Receptors, Interleukin-2 - immunology Receptors, Interleukin-2 - metabolism Regulatory factors and their cellular receptors Stromal cells T cell proliferation T cells T lymphocytes T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology
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Beschreibung
Zusammenfassung:	A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the β chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.8178155