Sex determination and dosage compensation: lessons from flies and worms

In both Drosophila melanogaster and Caenorhabditis elegans somatic sex determination, germline sex determination, and dosage compensation are controlled by means of a chromosomal signal known as the X:A ratio. A variety of mechanisms are used for establishing and implementing the chromosomal signal,...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1994-05, Vol.264 (5161), p.924-932
Hauptverfasser:	Parkhurst, S.M, Meneely, P.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Biological and medical sciences Caenorhabditis elegans Caenorhabditis elegans - genetics chromosomes dosage compensation Dosage compensation (Genetics) Dosage Compensation, Genetic Drosophila Drosophila melanogaster Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins Embryos Female Fundamental and applied biological sciences. Psychology Gene expression regulation General aspects General aspects and techniques. Study of several systematic groups. Models Genes Genes, Helminth Genes, Insect Genetic aspects Germ cells Humans Insect Hormones - genetics Invertebrates Male Male animals Mammals - genetics RNA-Binding Proteins Sex chromosomes Sex determination Sex determination (Genetics) Sex Determination Analysis Sex determination, Genetic Signal Transduction X chromosome
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Zusammenfassung:	In both Drosophila melanogaster and Caenorhabditis elegans somatic sex determination, germline sex determination, and dosage compensation are controlled by means of a chromosomal signal known as the X:A ratio. A variety of mechanisms are used for establishing and implementing the chromosomal signal, and these do not appear to be similar in the two species. Instead, the study of sex determination and dosage compensation is providing more general lessons of about different types of signalling pathways used to control alternative developmental states of cells and organisms.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.8178152