Effect of phenoxymethylpenicillin and erythromycin prophylaxis on anaerobic bacteraemia after oral surgery
The effect of antibiotic prophylaxis on bacteraemia was assessed in 60 oral surgery operations. Fifty-one patients were divided in three groups receiving a 2 g dose of phenoxymethylpenicillin, a 0·5 g dose of erythromycin or no prophylaxis. During operation, the total numbers of bacteria were lower...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1985-08, Vol.16 (2), p.243-251 |
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| container_end_page | 251 |
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| container_issue | 2 |
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| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 16 |
| creator | Josefsson, Kenneth Heimdahl, Anders von Konow, Lars Nord, Carl Erik |
| description | The effect of antibiotic prophylaxis on bacteraemia was assessed in 60 oral surgery operations. Fifty-one patients were divided in three groups receiving a 2 g dose of phenoxymethylpenicillin, a 0·5 g dose of erythromycin or no prophylaxis. During operation, the total numbers of bacteria were lower in the antibiotic groups than in the non-treatment groups (P |
| doi_str_mv | 10.1093/jac/16.2.243 |
| format | Article |
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Fifty-one patients were divided in three groups receiving a 2 g dose of phenoxymethylpenicillin, a 0·5 g dose of erythromycin or no prophylaxis. During operation, the total numbers of bacteria were lower in the antibiotic groups than in the non-treatment groups (P<0·05). The number of patients with anaerobic bacteraemias, however, were similar in all three groups. The incidences of bacteraemia 10 min after operation were significantly lower in the antibiotic groups (P<0·05). The minimum inhibitory concentrations (MICs) of phenoxymethylpenicillin were below 2 mg/l in 93% of the strains and the minimum bactericidal concentrations (MBCs) were below this value in 80% of the strains. The MICs of erythromycin were below 2 mg/l in 80% of the isolates, and the MBCs were between 4–32 mg/l in 62% of the isolates.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/16.2.243</identifier><identifier>PMID: 3934127</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacteria, Anaerobic - drug effects ; Biological and medical sciences ; Erythromycin - blood ; Erythromycin - therapeutic use ; Female ; Humans ; Male ; Medical sciences ; Microbial Sensitivity Tests ; Middle Aged ; Molar, Third - surgery ; Penicillin V - blood ; Penicillin V - therapeutic use ; Pharmacology. Drug treatments ; Premedication ; Saliva - microbiology ; Sepsis - prevention & control ; Tooth Extraction ; Tooth, Impacted - surgery</subject><ispartof>Journal of antimicrobial chemotherapy, 1985-08, Vol.16 (2), p.243-251</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c299t-e920412662c2f9f966ac79168f7be87ae420744f37dbc89b5c9bb0fc307368073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8513743$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3934127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Josefsson, Kenneth</creatorcontrib><creatorcontrib>Heimdahl, Anders</creatorcontrib><creatorcontrib>von Konow, Lars</creatorcontrib><creatorcontrib>Nord, Carl Erik</creatorcontrib><title>Effect of phenoxymethylpenicillin and erythromycin prophylaxis on anaerobic bacteraemia after oral surgery</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>The effect of antibiotic prophylaxis on bacteraemia was assessed in 60 oral surgery operations. Fifty-one patients were divided in three groups receiving a 2 g dose of phenoxymethylpenicillin, a 0·5 g dose of erythromycin or no prophylaxis. During operation, the total numbers of bacteria were lower in the antibiotic groups than in the non-treatment groups (P<0·05). The number of patients with anaerobic bacteraemias, however, were similar in all three groups. The incidences of bacteraemia 10 min after operation were significantly lower in the antibiotic groups (P<0·05). The minimum inhibitory concentrations (MICs) of phenoxymethylpenicillin were below 2 mg/l in 93% of the strains and the minimum bactericidal concentrations (MBCs) were below this value in 80% of the strains. The MICs of erythromycin were below 2 mg/l in 80% of the isolates, and the MBCs were between 4–32 mg/l in 62% of the isolates.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteria, Anaerobic - drug effects</subject><subject>Biological and medical sciences</subject><subject>Erythromycin - blood</subject><subject>Erythromycin - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Molar, Third - surgery</subject><subject>Penicillin V - blood</subject><subject>Penicillin V - therapeutic use</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Premedication</topic><topic>Saliva - microbiology</topic><topic>Sepsis - prevention & control</topic><topic>Tooth Extraction</topic><topic>Tooth, Impacted - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Josefsson, Kenneth</creatorcontrib><creatorcontrib>Heimdahl, Anders</creatorcontrib><creatorcontrib>von Konow, Lars</creatorcontrib><creatorcontrib>Nord, Carl Erik</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Josefsson, Kenneth</au><au>Heimdahl, Anders</au><au>von Konow, Lars</au><au>Nord, Carl Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of phenoxymethylpenicillin and erythromycin prophylaxis on anaerobic bacteraemia after oral surgery</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1985-08</date><risdate>1985</risdate><volume>16</volume><issue>2</issue><spage>243</spage><epage>251</epage><pages>243-251</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>The effect of antibiotic prophylaxis on bacteraemia was assessed in 60 oral surgery operations. Fifty-one patients were divided in three groups receiving a 2 g dose of phenoxymethylpenicillin, a 0·5 g dose of erythromycin or no prophylaxis. During operation, the total numbers of bacteria were lower in the antibiotic groups than in the non-treatment groups (P<0·05). The number of patients with anaerobic bacteraemias, however, were similar in all three groups. The incidences of bacteraemia 10 min after operation were significantly lower in the antibiotic groups (P<0·05). The minimum inhibitory concentrations (MICs) of phenoxymethylpenicillin were below 2 mg/l in 93% of the strains and the minimum bactericidal concentrations (MBCs) were below this value in 80% of the strains. The MICs of erythromycin were below 2 mg/l in 80% of the isolates, and the MBCs were between 4–32 mg/l in 62% of the isolates.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>3934127</pmid><doi>10.1093/jac/16.2.243</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of antimicrobial chemotherapy, 1985-08, Vol.16 (2), p.243-251 |
| issn | 0305-7453 1460-2091 |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adolescent Adult Aged Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria, Anaerobic - drug effects Biological and medical sciences Erythromycin - blood Erythromycin - therapeutic use Female Humans Male Medical sciences Microbial Sensitivity Tests Middle Aged Molar, Third - surgery Penicillin V - blood Penicillin V - therapeutic use Pharmacology. Drug treatments Premedication Saliva - microbiology Sepsis - prevention & control Tooth Extraction Tooth, Impacted - surgery |
| title | Effect of phenoxymethylpenicillin and erythromycin prophylaxis on anaerobic bacteraemia after oral surgery |
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