In Vitro Effects of Cinc/Gro, a Member of the Interleukin-8 Family, on Interleukin-6 Secretion by Rat Posterior Pituitary Cells

We investigated the effects of CINC/gro on IL-6 secretion by rat posterior pituitary cells. CINC/gro immunoreactivity was already detected in 1-h conditioned medium of normal posterior pituitary cells, and it increased significantly in a time-dependent manner during the first 24 h of culture. This i...

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Veröffentlicht in:	Biochemical and biophysical research communications 1994-04, Vol.200 (2), p.742-748
Hauptverfasser:	Sawada, T., Koike, K., Sakamoto, Y., Nohara, A., Kanda, Y., Zhang, Z.X., Ohmichi, M., Yamaguchi, M., Hirota, K., Miyake, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell physiology Cells, Cultured Chemokine CXCL1 Chemokines, CXC Chemotactic Factors - biosynthesis Chemotactic Factors - pharmacology Chemotactic Factors - secretion Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Growth Substances - biosynthesis Growth Substances - pharmacology Growth Substances - secretion Intercellular Signaling Peptides and Proteins Interleukin-6 - secretion Molecular and cellular biology Neuroimmunomodulation - drug effects Neuroimmunomodulation - physiology Pituitary Gland, Posterior - drug effects Pituitary Gland, Posterior - immunology Pituitary Gland, Posterior - physiology Rats Responses to growth factors, tumor promotors, other factors Tumor Necrosis Factor-alpha - administration & dosage Tumor Necrosis Factor-alpha - pharmacology Virulence Factors, Bordetella - pharmacology
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Zusammenfassung:	We investigated the effects of CINC/gro on IL-6 secretion by rat posterior pituitary cells. CINC/gro immunoreactivity was already detected in 1-h conditioned medium of normal posterior pituitary cells, and it increased significantly in a time-dependent manner during the first 24 h of culture. This immunoreactivity could be induced by TNF-α in a dose-dependent manner. On the other hand, CINC/gro stimulated IL-6 secretion by posterior pituitary monolayer cultures in a concentration dependent manner. Thus, CINC/gro significantly (P
ISSN:	0006-291X 1090-2104
DOI:	10.1006/bbrc.1994.1513