CIN in pregnancy: incidence, diagnosis and therapy

Over a period of 5 1/2 years, 71 cases of CIN in pregnancy were analysed. In this report, biological tumour behaviour, diagnostic procedures and therapy are discussed. In our study, there was a higher rate of remissions of light to moderate cervical intra-epithelial neoplasia (CIN I-II) in pregnancy than observed in non-pregnant women. In these cases, a conservative management was chosen. If diagnosis of CIN III or Cis (carcinoma in situ) in pregnancy occurred, the management was individualised, depending on gestational age, location of the lesion and extent of the lesion. Colposcopy, cytology and portio biopsy were used for diagnosis. Conisation was only performed in the 2nd. trimenon of pregnancy, if the lesion was large in size or mainly localised in the endocervix. No severe complications were seen. In any case of CIN III or Cis, conisation was performed 6 weeks after pregnancy.