Competitive in situ hybridization in a mediastinal germ cell tumor

We performed competitive in situ hybridization in a mediastinal germ cell tumor to identify chromosome 12 aberration(s). DNA from a mouse-human somatic hybrid cell line, containing an i(12p) as unique human material, was labeled and used as a probe. Our results confirm that the chromosome marker, ob...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1994-03, Vol.73 (1), p.53-56
Hauptverfasser:	Sayed Aly, Magdy, Dal Cin, Paola, Jiskoot, Peter, Deneffe, Georges, Marynen, Peter, Van den Berghe, Herman
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animals Biological and medical sciences chromosome 12 Chromosome Aberrations Chromosome Banding Chromosome Disorders Chromosomes, Human, Pair 12 germ cells Germinoma - genetics Germinoma - pathology Germinoma - therapy Humans Hybrid Cells In Situ Hybridization - methods inversion Male man Mediastinal Neoplasms - genetics Mediastinal Neoplasms - pathology Mediastinal Neoplasms - therapy Medical sciences Mice Pneumology tumors Tumors of the respiratory system and mediastinum
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Zusammenfassung:	We performed competitive in situ hybridization in a mediastinal germ cell tumor to identify chromosome 12 aberration(s). DNA from a mouse-human somatic hybrid cell line, containing an i(12p) as unique human material, was labeled and used as a probe. Our results confirm that the chromosome marker, observed in mediastinal germ cell tumor and cytogenetically identified as i(12p), is a true isochromosome of the short arm of chromosome 12.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(94)90181-3