Methotrexate inhibits the leukotriene B4 induced intraepidermal accumulation of polymorphonuclear leukocytes

SUMMARY The penetration of polymorphonuclear leukocytes (PMNs) into the epidermis following topical application of leukotriene B4 was assessed in the clinically uninvolved skin of psoriatic patients treated with methotrexate and of psoriatic patients without treatment, and in normal controls. Inhibi...

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Veröffentlicht in:	British journal of dermatology (1951) 1985-09, Vol.113 (3), p.251a-255a
Hauptverfasser:	VAN DE KERKHOF, P.C.M., BAUER, F.W., GROOD, R.M.MAASSEN-DE
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Chemotaxis, Leukocyte - drug effects Epidermis - pathology Female Humans Leukocytes - drug effects Leukotriene B4 - antagonists & inhibitors Male Medical sciences Methotrexate - therapeutic use Middle Aged Neutrophils - physiology Pharmacology. Drug treatments Psoriasis - drug therapy Psoriasis - pathology Skin, nail, hair, dermoskeleton
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Zusammenfassung:	SUMMARY The penetration of polymorphonuclear leukocytes (PMNs) into the epidermis following topical application of leukotriene B4 was assessed in the clinically uninvolved skin of psoriatic patients treated with methotrexate and of psoriatic patients without treatment, and in normal controls. Inhibition of PMN infiltration was observed in those patients treated with methotrexate while there was no significant difference between untreated psoriatic patients and normal controls.
ISSN:	0007-0963 1365-2133
DOI:	10.1111/j.1365-2133.1985.tb02075.x