Effect of partial stepwise luteectomy in pregnant gilts on maternal and fetal concentrations of progesterone

The number of corpora lutea (CL) in gilts was reduced to 8, 5, and 3 on Days 30, 40, and 50 of gestation, respectively. In a second group of gilts the number of CL was reduced to 5 by luteectomy by Day 50. Luteectomy did not affect concentrations of progesterone (P) in maternal uterine or fetal umbilical vessels sampled at Day 80. Concentration of P was higher in umbilical than uterine plasma in all treatments (P less than 0.01). The uterine arterial-venous (A/V) difference in concentrations of P was positive and the umbilical A/V difference was negative in all groups. The uterine and umbilical A/V differences at Day 80 decreased as the number of CL decreased. Fetal survival was reduced in luteectomized gilts. These results indicate that gradual reduction of numbers of CL does not result in placental secretion of P into the maternal circulation but does alter the uptake of P by the uterus and umbilical circulation.