Structural aspects of actin-binding proteins

Structural aspects of actin-binding proteins

The three-dimensional structures of myosin subfragment 1 (S1), gelsolin segment 1 complexed with α-actin, villin fragment 14T, Acanthamoeba profilin-1, and bovine profilin complexed with β-actin were completed last year. Together, they expand our understanding of the structural organization of actin...

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Veröffentlicht in:Current opinion in cell biology 1994-02, Vol.6 (1), p.87-95
Hauptverfasser: Rozycki, Michael D., Myslik, James C., Schutt, Clarence E., Lindberg, Uno
Format: Artikel
Sprache:eng
Schlagworte:
Actins - chemistry
Actins - metabolism
Amino Acid Sequence
Animals
Binding Sites
Carrier Proteins - chemistry
Carrier Proteins - metabolism
DNase I-deoxyribonuclease I
F-actin-filamentous actin
Gelsolin - chemistry
Gelsolin - metabolism
Humans
Microfilament Proteins - chemistry
Microfilament Proteins - metabolism
Models, Molecular
Molecular Sequence Data
Myosin Subfragments - chemistry
Myosin Subfragments - metabolism
PIP2-phosphatidylinositol 4,5-bisphosphate
Protein Structure, Secondary
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Zusammenfassung:The three-dimensional structures of myosin subfragment 1 (S1), gelsolin segment 1 complexed with α-actin, villin fragment 14T, Acanthamoeba profilin-1, and bovine profilin complexed with β-actin were completed last year. Together, they expand our understanding of the structural organization of actin-binding proteins. In additioin, the segment 1 and bovine profilin complexes provide atomic-level descriptions of their interfaces with actin.
ISSN:0955-0674
1879-0410
DOI:10.1016/0955-0674(94)90121-X