BE-23372M, A NOVEL PROTEIN TYROSINE KINASE INHIBITOR: II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION

BE-23372M, A NOVEL PROTEIN TYROSINE KINASE INHIBITOR: II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION

BE-23372M, a new protein tyrosine kinase inhibitor, has been obtained as a reddish orange solid. The compound, C17H12O6, HRFAB-MS: m/z 312.0625 (M)+, is an acidic substance, showing UV (MeOH)λmax (ε) 266 (8, 800), 426 nm (20, 400), and IR (KBr)νmax 1752(C=O) and 3298(OH) cm-1. The structure of BE-23...

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Veröffentlicht in:Journal of antibiotics 1994/03/25, Vol.47(3), pp.294-296
Hauptverfasser: TANAKA, SEIICHI, OKABE, TAKAYOSHI, NAKAJIMA, SIGERU, YOSHIDA, EISAKU, SUDA, HIROYUKI
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic agents
Biological and medical sciences
Chromatography, Thin Layer
Furans - chemistry
General aspects
Magnetic Resonance Spectroscopy
Medical sciences
Pharmacology. Drug treatments
Phenols - chemistry
Protein-Tyrosine Kinases - antagonists & inhibitors
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Ultraviolet
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Zusammenfassung:BE-23372M, a new protein tyrosine kinase inhibitor, has been obtained as a reddish orange solid. The compound, C17H12O6, HRFAB-MS: m/z 312.0625 (M)+, is an acidic substance, showing UV (MeOH)λmax (ε) 266 (8, 800), 426 nm (20, 400), and IR (KBr)νmax 1752(C=O) and 3298(OH) cm-1. The structure of BE-23372M, (E)-3-(3, 4-dihydroxybenzylidene)-5-(3, 4-dihydroxyphenyl)-2(3H)-furanone, has been elucidated by 1H and 13C NMR studies.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.47.294