Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors

The aim of this study was to investigate whether tumor‐induced cachexia and aberrations in host liver metabolism, induced by the MAT‐LyLu variant of the Dunning prostate tumor, could be prevented by ω3 fatty acids from fish oil. On day 0, adult Copenhagen‐Fisher rats fed normal chowad libitum were inoculated with 106 MAT‐LyLu cells (n=14) or saline (n=9). On day 7, when tumors were palpable, four tumor‐bearing (TB) and four nontumorbearing (NTB) rats were put on isocaloric diets with 50% of total energy as fish oil. The introduction of fish oil‐enriched diets caused a reduction in energy intake to less than half of the energy intake by animals fed normal diets during days 7–14 (difference by dietary group: NTB,P