A Randomized Trial of Single- and Two-Dose Ivermectin versus Thiabendazole for Treatment of Strongyloidiasis

A randomized trial is described comparing ivermectin and thiabendazole for treatment of chronic infection with Strongyloides stercoralis. Subjects received ivermectin (200 µg/kg) in a single dose, ivermectin (200 µg/kg) on 2 consecutive days, or thiabendazole (50 mg/kg/day) twice daily for 3 consecu...

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Veröffentlicht in:The Journal of infectious diseases 1994-05, Vol.169 (5), p.1076-1079
Hauptverfasser: Gann, Peter H., Neva, Franklin A., Gam, Albert A.
Format: Artikel
Sprache:eng
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Zusammenfassung:A randomized trial is described comparing ivermectin and thiabendazole for treatment of chronic infection with Strongyloides stercoralis. Subjects received ivermectin (200 µg/kg) in a single dose, ivermectin (200 µg/kg) on 2 consecutive days, or thiabendazole (50 mg/kg/day) twice daily for 3 consecutive days. Most subjects (94%) had intermittent symptoms, including urticaria, epigastric pain, and diarrhea. Stools were examined 7 days and 1, 3, 6, 10, and 22 months after treatment. Fifty-three subjects completed at least 3 months of follow-up. Only 1 of 34 and 2 of 19 ivermectin and thiabendazole subjects, respectively, had a stool positive for larvae after treatment. Symptoms were relieved in all 3 groups and eosinophil levels returned to normal in 90% of all subjects by 12 months. Nearly 95% of thiabendazole subjects had short-term adverse effects during therapy versus only 18% of those treated with ivermectin. One dose of ivermectin provides safety and efficacye quivalent to thiabendazole with a much lower prevalence of side effects and, consequently, better compliance.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/169.5.1076