Concise Synthesis of the Oxapentacyclic Core of Cortistatin A

Concise Synthesis of the Oxapentacyclic Core of Cortistatin A

A concise synthetic approach for constructing the oxapentacyclic framework of cortistatin A is described. The synthesis features a furan−oxyallyl [4 + 3] cycloaddition and double-intramolecular aldol reactions. In addition, an interesting core structure was obtained in 11 steps from furan by using o...

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Veröffentlicht in:Organic letters 2010-11, Vol.12 (22), p.5135-5137
Hauptverfasser: Yu, Fangmiao, Li, Guozhi, Gao, Peng, Gong, Hongju, Liu, Yinghua, Wu, Yongming, Cheng, Bin, Zhai, Hongbin
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cyclization
Marine Biology
Molecular Structure
Polycyclic Compounds - chemical synthesis
Polycyclic Compounds - chemistry
Porifera - chemistry
Stereoisomerism
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Zusammenfassung:A concise synthetic approach for constructing the oxapentacyclic framework of cortistatin A is described. The synthesis features a furan−oxyallyl [4 + 3] cycloaddition and double-intramolecular aldol reactions. In addition, an interesting core structure was obtained in 11 steps from furan by using our method.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol102058f