Single unit activity in frontal cortex and caudate nucleus of young and old rats
Spontaneous neuronal activity was recorded extracellularly from isolated single units in frontal neocortex and caudate nucleus of young and aged F344 rats anesthetized with urethane. Average firing rates, mean interspike intervals (ISI)±standard deviations, and ISI frequency histograms were computed...
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| Veröffentlicht in: | Neurobiology of aging 1985-01, Vol.6 (3), p.245-248 |
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| container_title | Neurobiology of aging |
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| creator | Stern, Warren C. Pugh, William W. Morgane, Peter J. |
| description | Spontaneous neuronal activity was recorded extracellularly from isolated single units in frontal neocortex and caudate nucleus of young and aged F344 rats anesthetized with urethane. Average firing rates, mean interspike intervals (ISI)±standard deviations, and ISI frequency histograms were computed and analyzed by microprocessor. For frontal cortex cells (N=226), there was a nonsignificant trend toward slower average discharge rates in the old group. However, a significantly longer mean ISI and proportionally more very slow firing cells ( |
| doi_str_mv | 10.1016/0197-4580(85)90058-2 |
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Average firing rates, mean interspike intervals (ISI)±standard deviations, and ISI frequency histograms were computed and analyzed by microprocessor. For frontal cortex cells (N=226), there was a nonsignificant trend toward slower average discharge rates in the old group. However, a significantly longer mean ISI and proportionally more very slow firing cells (<I Hz) were observed in old rats. A laminar analysis of frontal cortex unit activity in young animals showed average discharge rates to be distributed somewhat evenly throughout the cortical mantle with the exception of the zone 1200–1400 μ beneath brain surface. This depth corresponds approximately to layer V where a 50% increase in mean firing rate in young animals was observed. In aged animals, this increased cell firing in layer V was absent, while mean discharge rates in other laminae remained essentially the same in the young and old rat groups. Caudate nucleus cells (n=70) showed a significant shift towards fewer fast discharging cells in old rats, with the average firing rate diminished by one-third. Although more brain regions need to be examined in a similar fashion, the consistency of the present results with those previously reported for the brainstem and cerebellum suggests that slower firing rates and longer ISIs are likely to be wide-spread throughout the brains of aged rats.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/0197-4580(85)90058-2</identifier><identifier>PMID: 4058653</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Action Potentials ; Aging ; Animals ; Biological and medical sciences ; Caudate nucleus ; Caudate Nucleus - physiology ; Central nervous system ; Electrophysiology ; Frontal Lobe - physiology ; Frontal neocortex ; Fundamental and applied biological sciences. 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Average firing rates, mean interspike intervals (ISI)±standard deviations, and ISI frequency histograms were computed and analyzed by microprocessor. For frontal cortex cells (N=226), there was a nonsignificant trend toward slower average discharge rates in the old group. However, a significantly longer mean ISI and proportionally more very slow firing cells (<I Hz) were observed in old rats. A laminar analysis of frontal cortex unit activity in young animals showed average discharge rates to be distributed somewhat evenly throughout the cortical mantle with the exception of the zone 1200–1400 μ beneath brain surface. This depth corresponds approximately to layer V where a 50% increase in mean firing rate in young animals was observed. In aged animals, this increased cell firing in layer V was absent, while mean discharge rates in other laminae remained essentially the same in the young and old rat groups. Caudate nucleus cells (n=70) showed a significant shift towards fewer fast discharging cells in old rats, with the average firing rate diminished by one-third. Although more brain regions need to be examined in a similar fashion, the consistency of the present results with those previously reported for the brainstem and cerebellum suggests that slower firing rates and longer ISIs are likely to be wide-spread throughout the brains of aged rats.</description><subject>Action Potentials</subject><subject>Aging</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Caudate nucleus</subject><subject>Caudate Nucleus - physiology</subject><subject>Central nervous system</subject><subject>Electrophysiology</subject><subject>Frontal Lobe - physiology</subject><subject>Frontal neocortex</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Laminar analysis</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Spontaneous single unit activity</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LXDEQhkOx6Gr7DyrkQkQvTpvk5OvcCCJqC0IL1esQcyaScjaxSY50_71Zd9nLejVh3meGyYPQF0q-UkLlN0IH1XGhyZkW5wMhQnfsA1pQ0R6UD2oPLXbIATos5Q8hRHEl99E-b7QU_QL9-h3i0wR4jqFi62p4CXWFQ8Q-p1jthF3KFf5hG0fs7DzaCjjOboK54OTxKs3x6S1M04izreUT-ujtVODzth6hh5vr-6vv3d3P2x9Xl3ed41TVTvmhdxoGJqVQhEkvrQLuoefCeikeeS976YXtB-2sYJ5B-xJwrgUbW5f0R-h0s_c5p78zlGqWoTiYJhshzcUoyQWng3gXpJzJnlHdQL4BXU6lZPDmOYelzStDiVkbN2udZq3TaGHejBvWxo63--fHJYy7oa3ilp9sc1ucnXy20YWyw7SQUnHZsIsNBk3aS4BsigsQHYwhg6tmTOH_d7wC6PibQw</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Stern, Warren C.</creator><creator>Pugh, William W.</creator><creator>Morgane, Peter J.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19850101</creationdate><title>Single unit activity in frontal cortex and caudate nucleus of young and old rats</title><author>Stern, Warren C. ; Pugh, William W. ; Morgane, Peter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7f93c8e926657026f6a7e4fe345af65b43636f5a398ca52f2e149e44852d5a303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Action Potentials</topic><topic>Aging</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Caudate nucleus</topic><topic>Caudate Nucleus - physiology</topic><topic>Central nervous system</topic><topic>Electrophysiology</topic><topic>Frontal Lobe - physiology</topic><topic>Frontal neocortex</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Laminar analysis</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Spontaneous single unit activity</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stern, Warren C.</creatorcontrib><creatorcontrib>Pugh, William W.</creatorcontrib><creatorcontrib>Morgane, Peter J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stern, Warren C.</au><au>Pugh, William W.</au><au>Morgane, Peter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single unit activity in frontal cortex and caudate nucleus of young and old rats</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>6</volume><issue>3</issue><spage>245</spage><epage>248</epage><pages>245-248</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Spontaneous neuronal activity was recorded extracellularly from isolated single units in frontal neocortex and caudate nucleus of young and aged F344 rats anesthetized with urethane. Average firing rates, mean interspike intervals (ISI)±standard deviations, and ISI frequency histograms were computed and analyzed by microprocessor. For frontal cortex cells (N=226), there was a nonsignificant trend toward slower average discharge rates in the old group. However, a significantly longer mean ISI and proportionally more very slow firing cells (<I Hz) were observed in old rats. A laminar analysis of frontal cortex unit activity in young animals showed average discharge rates to be distributed somewhat evenly throughout the cortical mantle with the exception of the zone 1200–1400 μ beneath brain surface. This depth corresponds approximately to layer V where a 50% increase in mean firing rate in young animals was observed. In aged animals, this increased cell firing in layer V was absent, while mean discharge rates in other laminae remained essentially the same in the young and old rat groups. Caudate nucleus cells (n=70) showed a significant shift towards fewer fast discharging cells in old rats, with the average firing rate diminished by one-third. Although more brain regions need to be examined in a similar fashion, the consistency of the present results with those previously reported for the brainstem and cerebellum suggests that slower firing rates and longer ISIs are likely to be wide-spread throughout the brains of aged rats.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>4058653</pmid><doi>10.1016/0197-4580(85)90058-2</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neurobiology of aging, 1985-01, Vol.6 (3), p.245-248 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Action Potentials Aging Animals Biological and medical sciences Caudate nucleus Caudate Nucleus - physiology Central nervous system Electrophysiology Frontal Lobe - physiology Frontal neocortex Fundamental and applied biological sciences. Psychology Laminar analysis Male Rats Rats, Inbred F344 Spontaneous single unit activity Vertebrates: nervous system and sense organs |
| title | Single unit activity in frontal cortex and caudate nucleus of young and old rats |
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