Single unit activity in frontal cortex and caudate nucleus of young and old rats

Spontaneous neuronal activity was recorded extracellularly from isolated single units in frontal neocortex and caudate nucleus of young and aged F344 rats anesthetized with urethane. Average firing rates, mean interspike intervals (ISI)±standard deviations, and ISI frequency histograms were computed...

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Veröffentlicht in:	Neurobiology of aging 1985-01, Vol.6 (3), p.245-248
Hauptverfasser:	Stern, Warren C., Pugh, William W., Morgane, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Aging Animals Biological and medical sciences Caudate nucleus Caudate Nucleus - physiology Central nervous system Electrophysiology Frontal Lobe - physiology Frontal neocortex Fundamental and applied biological sciences. Psychology Laminar analysis Male Rats Rats, Inbred F344 Spontaneous single unit activity Vertebrates: nervous system and sense organs
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Zusammenfassung:	Spontaneous neuronal activity was recorded extracellularly from isolated single units in frontal neocortex and caudate nucleus of young and aged F344 rats anesthetized with urethane. Average firing rates, mean interspike intervals (ISI)±standard deviations, and ISI frequency histograms were computed and analyzed by microprocessor. For frontal cortex cells (N=226), there was a nonsignificant trend toward slower average discharge rates in the old group. However, a significantly longer mean ISI and proportionally more very slow firing cells (
ISSN:	0197-4580 1558-1497
DOI:	10.1016/0197-4580(85)90058-2