Enamel matrix derivative proteins for the treatment of proximal class II furcation involvements: a prospective 24-month randomized clinical trial

Casarin RCV, Ribeiro ÉDP, Nociti Jr FH, Sallum AW, Ambrosano GMB, Sallum EA, Casati MZ: Enamel matrix derivative proteins for the treatment of proximal class II furcation involvements: a prospective 24‐month randomized clinical trial. J Clin Periodontol 2010; doi: 10.1111/j.1600‐051X.2010.01614.x. Objective: This study aimed to evaluate the response of proximal furcations treated with enamel matrix derivative proteins (EMD) in a 24‐month follow‐up. Materials and Methods: Twelve patients presenting bilateral class II proximal furcation with vertical probing depth (PD)5 mm and bleeding on probing were selected. The furcations were assigned to: a control group (n=12), open flap debridement (OFD)+EDTA and a test group (n=12) – OFD+EDTA+EMD. The gingival margin position, PD, relative vertical and horizontal clinical attachment level (RVCAL and RHCAL), vertical and horizontal bone level (VBL and HBL) and furcation closure were evaluated before treatment and after 6, 12 and 24 months. Results: After follow‐up, no statistical difference could be seen between groups. At 24 months, the test group showed 1.9 ± 1.6 mm PD reduction whereas the control group showed 1.0 ± 1.3 mm PD reduction. RHCAL gains of the control and the test group were 0.7 ± 1.3 and 1.4 ± 0.9 mm, respectively. However, at 24 months, the test group only presented five remaining class II furcations versus 10 furcations in the control group (p